1szi

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[[Image:1szi.gif|left|200px]]
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{{STRUCTURE_1szi| PDB=1szi | SCENE= }}
{{STRUCTURE_1szi| PDB=1szi | SCENE= }}
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'''Crystal Structure of the C-terminus of TIP47'''
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===Crystal Structure of the C-terminus of TIP47===
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==Overview==
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The perilipin/ADRP/TIP47 (PAT) proteins localize to the surface of intracellular neutral lipid droplets. Perilipin is essential for lipid storage and hormone regulated lipolysis in adipocytes, and perilipin null mice exhibit a dramatic reduction in adipocyte lipid stores. A significant fraction of the approximately 200 amino acid N-terminal region of the PAT proteins consists of 11-mer helical repeats that are also found in apolipoproteins and other lipid-associated proteins. The C-terminal 60% of TIP47, a representative PAT protein, comprises a monomeric and independently folded unit. The crystal structure of the C-terminal portion of TIP47 was determined and refined at 2.8 A resolution. The structure consists of an alpha/beta domain of novel topology and a four-helix bundle resembling the LDL receptor binding domain of apolipoprotein E. The structure suggests an analogy between PAT proteins and apolipoproteins in which helical repeats interact with lipid while the ordered C-terminal region is involved in protein:protein interactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 15242596 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15242596}}
==About this Structure==
==About this Structure==
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[[Category: Alpha/beta domain]]
[[Category: Alpha/beta domain]]
[[Category: Pat protein]]
[[Category: Pat protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:18:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:40:31 2008''

Revision as of 22:40, 28 July 2008

Image:1szi.png

Template:STRUCTURE 1szi

Crystal Structure of the C-terminus of TIP47

Template:ABSTRACT PUBMED 15242596

About this Structure

1SZI is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of a lipid droplet protein; the PAT family member TIP47., Hickenbottom SJ, Kimmel AR, Londos C, Hurley JH, Structure. 2004 Jul;12(7):1199-207. PMID:15242596

Page seeded by OCA on Tue Jul 29 01:40:31 2008

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