2iz9

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[[Image:2iz9.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2iz9| PDB=2iz9 | SCENE= }}
{{STRUCTURE_2iz9| PDB=2iz9 | SCENE= }}
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'''MS2-RNA HAIRPIN (4ONE-5) COMPLEX'''
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===MS2-RNA HAIRPIN (4ONE-5) COMPLEX===
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==Overview==
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The MS2 coat protein binds specifically to an RNA hairpin formed within the viral genome. By soaking different RNA fragments into crystals of MS2 coat protein capsids it is possible to determine the X-ray structure of the RNA-protein complexes formed. Here we present the structure to 2.85 A resolution of a complex between a chemically modified RNA hairpin variant and the MS2 coat protein. This RNA variant has a substitution at the -5 base position, which has been shown previously to be pyrimidine-specific and is a uracil in the wild-type RNA. The modified RNA hairpin contains a pyridin-4-one base (4one) at this position that lacks the exocyclic 2-oxygen eliminating the possibility of forming a hydrogen bond to asparagine A87 in the protein. The 4one complex structure shows an unprecedented major conformational change in the loop region of the RNA, whereas there is almost no change in the conformation of the protein.
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The line below this paragraph, {{ABSTRACT_PUBMED_11095669}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11095669 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11095669}}
==About this Structure==
==About this Structure==
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[[Category: Levivirus]]
[[Category: Levivirus]]
[[Category: Virus]]
[[Category: Virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:06:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:42:02 2008''

Revision as of 22:42, 28 July 2008

Image:2iz9.png

Template:STRUCTURE 2iz9

MS2-RNA HAIRPIN (4ONE-5) COMPLEX

Template:ABSTRACT PUBMED 11095669

About this Structure

2IZ9 is a Single protein structure of sequence from Enterobacterio phage ms2. This structure supersedes the now removed PDB entry 1dzs. Full crystallographic information is available from OCA.

Reference

Deletion of a single hydrogen bonding atom from the MS2 RNA operator leads to dramatic rearrangements at the RNA-coat protein interface., Grahn E, Stonehouse NJ, Adams CJ, Fridborg K, Beigelman L, Matulic-Adamic J, Warriner SL, Stockley PG, Liljas L, Nucleic Acids Res. 2000 Dec 1;28(23):4611-6. PMID:11095669

Page seeded by OCA on Tue Jul 29 01:42:02 2008

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