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2bby

From Proteopedia

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{{STRUCTURE_2bby| PDB=2bby | SCENE= }}
{{STRUCTURE_2bby| PDB=2bby | SCENE= }}
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'''DNA-BINDING DOMAIN FROM HUMAN RAP30, NMR, 30 STRUCTURES'''
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===DNA-BINDING DOMAIN FROM HUMAN RAP30, NMR, 30 STRUCTURES===
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==Overview==
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The three-dimensional structure of the human Rap30 DNA-binding domain has been solved by multinuclear NMR spectroscopy. The structure of the globular domain is strikingly similar to that of linker histone H5 and its fold places Rap30 into the "winged" helix-turn-helix family of eukaryotic transcription factors. Although the domain interacts weakly with DNA, the binding surface was identified and shown to be consistent with the structure of the HNF-3/fork head-DNA complex. The architecture of the Rap30 DNA-binding domain has important implications for the function of Rap30 in the assembly of the preinitiation complex. In analogy to the function of linker histones in chromatin formation, the fold of the Rap30 DNA-binding domain suggests that its role in transcription initiation may be that of a condensation factor for preinitiation complex assembly. Functional similarity to linker histones may explain the dependence of Rap30 binding on the bent DNA environment induced by the TATA box-binding protein. Cryptic sequence identity and functional homology between the Rap30 DNA-binding domain and region 4 of Escherichia coli sigma70 may indicate that the sigma factors also possess a linker histone-like activity in the formation of a prokaryotic closed complex.
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{{ABSTRACT_PUBMED_9689043}}
==About this Structure==
==About this Structure==
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2BBY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBY OCA].
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2BBY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBY OCA].
==Reference==
==Reference==
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[[Category: Rap30]]
[[Category: Rap30]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:05:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:44:16 2008''

Revision as of 22:44, 28 July 2008

Image:2bby.png

Template:STRUCTURE 2bby

DNA-BINDING DOMAIN FROM HUMAN RAP30, NMR, 30 STRUCTURES

Template:ABSTRACT PUBMED 9689043

About this Structure

2BBY is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural homology between the Rap30 DNA-binding domain and linker histone H5: implications for preinitiation complex assembly., Groft CM, Uljon SN, Wang R, Werner MH, Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9117-22. PMID:9689043

Page seeded by OCA on Tue Jul 29 01:44:16 2008

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