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1t34

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[[Image:1t34.jpg|left|200px]]
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{{STRUCTURE_1t34| PDB=1t34 | SCENE= }}
{{STRUCTURE_1t34| PDB=1t34 | SCENE= }}
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'''ROTATION MECHANISM FOR TRANSMEMBRANE SIGNALING BY THE ATRIAL NATRIURETIC PEPTIDE RECEPTOR'''
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===ROTATION MECHANISM FOR TRANSMEMBRANE SIGNALING BY THE ATRIAL NATRIURETIC PEPTIDE RECEPTOR===
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==Overview==
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A cardiac hormone, atrial natriuretic peptide (ANP), plays a major role in blood pressure and volume regulation. ANP activities are mediated by a single span transmembrane receptor carrying intrinsic guanylate cyclase activity. ANP binding to its extracellular domain stimulates guanylate cyclase activity by an as yet unknown mechanism. Here we report the crystal structure of dimerized extracellular hormone-binding domain in complex with ANP. The structural comparison with the unliganded receptor reveals that hormone binding causes the two receptor monomers to undergo an intermolecular twist with little intramolecular conformational change. This motion produces a Ferris wheel-like translocation of two juxtamembrane domains in the dimer with essentially no change in the interdomain distance. This movement alters the relative orientation of the two domains by a shift equivalent to counterclockwise rotation of each by 24 degrees. These results suggest that transmembrane signaling by the ANP receptor is initiated via a hormone-induced rotation mechanism.
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The line below this paragraph, {{ABSTRACT_PUBMED_15117952}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15117952 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15117952}}
==About this Structure==
==About this Structure==
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[[Category: Rotation mechanism]]
[[Category: Rotation mechanism]]
[[Category: Signal transduction]]
[[Category: Signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:27:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:46:49 2008''

Revision as of 22:47, 28 July 2008

Image:1t34.png

Template:STRUCTURE 1t34

ROTATION MECHANISM FOR TRANSMEMBRANE SIGNALING BY THE ATRIAL NATRIURETIC PEPTIDE RECEPTOR

Template:ABSTRACT PUBMED 15117952

About this Structure

1T34 is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of hormone-bound atrial natriuretic peptide receptor extracellular domain: rotation mechanism for transmembrane signal transduction., Ogawa H, Qiu Y, Ogata CM, Misono KS, J Biol Chem. 2004 Jul 2;279(27):28625-31. Epub 2004 Apr 26. PMID:15117952

Page seeded by OCA on Tue Jul 29 01:46:49 2008

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