2raj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2raj.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2raj.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2raj| PDB=2raj | SCENE= }}
{{STRUCTURE_2raj| PDB=2raj | SCENE= }}
-
'''SO4 bound PX-BAR membrane remodeling unit of Sorting Nexin 9'''
+
===SO4 bound PX-BAR membrane remodeling unit of Sorting Nexin 9===
-
==Overview==
+
<!--
-
Sorting nexins (SNXs) form a family of proteins known to interact with components in the endosomal system and to regulate various steps of vesicle transport. Sorting nexin 9 (SNX9) is involved in the late stages of clathrin-mediated endocytosis in non-neuronal cells, where together with the GTPase dynamin, it participates in the formation and scission of the vesicle neck. We report here crystal structures of the functional membrane-remodeling unit of SNX9 and show that it efficiently tubulates lipid membranes in vivo and in vitro. Elucidation of the protein superdomain structure, together with mutational analysis and biochemical and cell biological experiments, demonstrated how the SNX9 PX and BAR domains work in concert in targeting and tubulation of phosphoinositide-containing membranes. The study provides insights into the SNX9-induced membrane modulation mechanism.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17948057}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17948057 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17948057}}
==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Structural protein]]
[[Category: Structural protein]]
[[Category: Tubulation]]
[[Category: Tubulation]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:33:00 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:53:03 2008''

Revision as of 22:53, 28 July 2008

Image:2raj.png

Template:STRUCTURE 2raj

SO4 bound PX-BAR membrane remodeling unit of Sorting Nexin 9

Template:ABSTRACT PUBMED 17948057

About this Structure

2RAJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The PX-BAR membrane-remodeling unit of sorting nexin 9., Pylypenko O, Lundmark R, Rasmuson E, Carlsson SR, Rak A, EMBO J. 2007 Nov 14;26(22):4788-800. Epub 2007 Oct 18. PMID:17948057

Page seeded by OCA on Tue Jul 29 01:53:03 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2raj"
Personal tools