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2q5g

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{{STRUCTURE_2q5g| PDB=2q5g | SCENE= }}
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'''Ligand binding domain of PPAR delta receptor in complex with a partial agonist'''
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===Ligand binding domain of PPAR delta receptor in complex with a partial agonist===
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==Overview==
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Structure based ligand design was used in order to design a partial agonist for the PPARdelta receptor. The maximum activation in the transactivation assay was reduced from 87% to 39%. The crystal structure of the ligand binding domain of the PPARdelta receptor in complex with compound 2 was determined in order to understand the structural changes which gave rise to the decrease in maximum activation.
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(as it appears on PubMed at http://www.pubmed.gov), where 17560785 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17560785}}
==About this Structure==
==About this Structure==
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[[Category: Ppar delta]]
[[Category: Ppar delta]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 4 09:51:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:55:04 2008''

Revision as of 22:55, 28 July 2008

Image:2q5g.png

Template:STRUCTURE 2q5g

Ligand binding domain of PPAR delta receptor in complex with a partial agonist

Template:ABSTRACT PUBMED 17560785

About this Structure

2Q5G is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Design of a partial PPARdelta agonist., Pettersson I, Ebdrup S, Havranek M, Pihera P, Korinek M, Mogensen JP, Jeppesen CB, Johansson E, Sauerberg P, Bioorg Med Chem Lett. 2007 Aug 15;17(16):4625-9. Epub 2007 May 27. PMID:17560785

Page seeded by OCA on Tue Jul 29 01:55:04 2008

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