1yo4

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[[Image:1yo4.gif|left|200px]]
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{{STRUCTURE_1yo4| PDB=1yo4 | SCENE= }}
{{STRUCTURE_1yo4| PDB=1yo4 | SCENE= }}
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'''Solution Structure of the SARS Coronavirus ORF 7a coded X4 protein'''
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===Solution Structure of the SARS Coronavirus ORF 7a coded X4 protein===
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==Overview==
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The SARS related Coronavirus genome contains a variety of novel accessory genes. One of these, called ORF7a or ORF8, code for a protein, known as 7a, U122 or X4. We set out to determine the three-dimensional structure of the soluble ectodomain of this type-I transmembrane protein by nuclear magnetic resonance spectroscopy. The fold of the protein is the first member of a further variation of the immunoglobulin like beta-sandwich fold. Because X4 does not reveal significant sequence homologies to proteins in the data bases, we carried out a structure based similarity search for proteins with known function. High structural similarity to Dl domains of ICAM-1 and ICAM-2, and common features in amino acid sequence between X4 and ICAM-1, suggest X4 to possess binding activity for the alpha(L) integrin I domain of LFA-1. Further, based on this structure based prediction, potential functions of X4 in virus replication and pathogenesis are discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 16328780 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16328780}}
==About this Structure==
==About this Structure==
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1YO4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YO4 OCA].
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1YO4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YO4 OCA].
==Reference==
==Reference==
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[[Category: Beta-sandwich]]
[[Category: Beta-sandwich]]
[[Category: Immunoglobulin-like domain]]
[[Category: Immunoglobulin-like domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:34:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:06:31 2008''

Revision as of 23:06, 28 July 2008

Image:1yo4.png

Template:STRUCTURE 1yo4

Solution Structure of the SARS Coronavirus ORF 7a coded X4 protein

Template:ABSTRACT PUBMED 16328780

About this Structure

1YO4 is a Single protein structure of sequence from Sars coronavirus. Full experimental information is available from OCA.

Reference

Solution structure of the X4 protein coded by the SARS related coronavirus reveals an immunoglobulin like fold and suggests a binding activity to integrin I domains., Hanel K, Stangler T, Stoldt M, Willbold D, J Biomed Sci. 2006 May;13(3):281-93. Epub 2005 Nov 23. PMID:16328780

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