2rft

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{{STRUCTURE_2rft| PDB=2rft | SCENE= }}
{{STRUCTURE_2rft| PDB=2rft | SCENE= }}
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'''Crystal structure of influenza B virus hemagglutinin in complex with LSTa receptor analog'''
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===Crystal structure of influenza B virus hemagglutinin in complex with LSTa receptor analog===
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==Overview==
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Receptor-binding specificity of HA, the major surface glycoprotein of influenza virus, primarily determines the host ranges that the virus can infect. Influenza type B virus almost exclusively infects humans and contributes to the annual "flu" sickness. Here we report the structures of influenza B virus HA in complex with human and avian receptor analogs, respectively. These structures provide a structural basis for the different receptor-binding properties of influenza A and B virus HA molecules and for the ability of influenza B virus HA to distinguish human and avian receptors. The structure of influenza B virus HA with avian receptor analog also reveals how mutations in the region of residues 194 to 196, which are frequently observed in egg-adapted and naturally occurring variants, directly affect the receptor binding of the resultant virus strains. Furthermore, these structures of influenza B virus HA are compared with known structures of influenza A virus HAs, which suggests the role of the residue at 222 as a key and likely a universal determinant for the different binding modes of human receptor analogs by different HA molecules.
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(as it appears on PubMed at http://www.pubmed.gov), where 17942670 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17942670}}
==About this Structure==
==About this Structure==
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[[Category: Viral protein]]
[[Category: Viral protein]]
[[Category: Virion]]
[[Category: Virion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:50:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:11:43 2008''

Revision as of 23:11, 28 July 2008

Image:2rft.png

Template:STRUCTURE 2rft

Crystal structure of influenza B virus hemagglutinin in complex with LSTa receptor analog

Template:ABSTRACT PUBMED 17942670

About this Structure

2RFT is a Protein complex structure of sequences from Influenza b virus. Full crystallographic information is available from OCA.

Reference

Structural basis for receptor specificity of influenza B virus hemagglutinin., Wang Q, Tian X, Chen X, Ma J, Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16874-9. Epub 2007 Oct 17. PMID:17942670

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