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2i83

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[[Image:2i83.gif|left|200px]]
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{{Seed}}
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[[Image:2i83.png|left|200px]]
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{{STRUCTURE_2i83| PDB=2i83 | SCENE= }}
{{STRUCTURE_2i83| PDB=2i83 | SCENE= }}
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'''hyaluronan-binding domain of CD44 in its ligand-bound form'''
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===hyaluronan-binding domain of CD44 in its ligand-bound form===
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==Overview==
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CD44, a major cell surface receptor for hyaluronan (HA), contains a functional domain responsible for HA binding at its N terminus (residues 21-178). Accumulating evidence indicates that proteolytic cleavage of CD44 in its extracellular region (residues 21-268) leads to enhanced tumor cell migration and invasion. Hence, understanding the mechanisms underlying the CD44 proteolytic cleavage is important for understanding the mechanism of CD44-mediated tumor progression. Here we present the NMR structure of the HA-binding domain of CD44 in its HA-bound state. The structure is composed of the Link module (residues 32-124) and an extended lobe (residues 21-31 and 125-152). Interestingly, a comparison of its unbound and HA-bound structures revealed that rearrangement of the beta-strands in the extended lobe (residues 143-148) and disorder of the structure in the following C-terminal region (residues 153-169) occurred upon HA binding, which is consistent with the results of trypsin proteolysis studies of the CD44 HA-binding domain. The order-to-disorder transition of the C-terminal region by HA binding may be involved in the CD44-mediated cell migration.
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The line below this paragraph, {{ABSTRACT_PUBMED_17085435}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17085435 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17085435}}
==About this Structure==
==About this Structure==
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2I83 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I83 OCA].
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2I83 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I83 OCA].
==Reference==
==Reference==
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[[Category: Umemoto, R.]]
[[Category: Umemoto, R.]]
[[Category: Link module]]
[[Category: Link module]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:11:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:20:23 2008''

Revision as of 23:20, 28 July 2008

Image:2i83.png

Template:STRUCTURE 2i83

hyaluronan-binding domain of CD44 in its ligand-bound form

Template:ABSTRACT PUBMED 17085435

About this Structure

2I83 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Ligand-induced structural changes of the CD44 hyaluronan-binding domain revealed by NMR., Takeda M, Ogino S, Umemoto R, Sakakura M, Kajiwara M, Sugahara KN, Hayasaka H, Miyasaka M, Terasawa H, Shimada I, J Biol Chem. 2006 Dec 29;281(52):40089-95. Epub 2006 Nov 2. PMID:17085435

Page seeded by OCA on Tue Jul 29 02:20:23 2008

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