2i2y

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[[Image:2i2y.gif|left|200px]]
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{{STRUCTURE_2i2y| PDB=2i2y | SCENE= }}
{{STRUCTURE_2i2y| PDB=2i2y | SCENE= }}
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'''Solution structure of the RRM of SRp20 bound to the RNA CAUC'''
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===Solution structure of the RRM of SRp20 bound to the RNA CAUC===
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==Overview==
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The sequence-specific RNA-binding proteins SRp20 and 9G8 are the smallest members of the serine- and arginine-rich (SR) protein family, well known for their role in splicing. They also play a role in mRNA export, in particular of histone mRNAs. We present the solution structures of the free 9G8 and SRp20 RNA recognition motifs (RRMs) and of SRp20 RRM in complex with the RNA sequence 5'CAUC3'. The SRp20-RNA structure reveals that although all 4 nt are contacted by the RRM, only the 5' cytosine is primarily recognized in a specific way. This might explain the numerous consensus sequences found by SELEX (systematic evolution of ligands by exponential enrichment) for the RRM of 9G8 and SRp20. Furthermore, we identify a short arginine-rich peptide adjacent to the SRp20 and 9G8 RRMs, which does not contact RNA but is necessary and sufficient for interaction with the export factor Tip-associated protein (TAP). Together, these results provide a molecular description for mRNA and TAP recognition by SRp20 and 9G8.
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The line below this paragraph, {{ABSTRACT_PUBMED_17036044}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17036044 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17036044}}
==About this Structure==
==About this Structure==
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2I2Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_sp._group_g_and_homo_sapiens Streptococcus sp. group g and homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2Y OCA].
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2I2Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_sp._group_g_and_homo_sapiens Streptococcus sp. group g and homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2Y OCA].
==Reference==
==Reference==
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[[Category: Hargous, Y F.]]
[[Category: Hargous, Y F.]]
[[Category: Protein-rna complex rrm alpha-beta sandwich beta1-alpha1-beta2-beta3-alpha2-beta4]]
[[Category: Protein-rna complex rrm alpha-beta sandwich beta1-alpha1-beta2-beta3-alpha2-beta4]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:00:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:20:40 2008''

Revision as of 23:20, 28 July 2008

Image:2i2y.png

Template:STRUCTURE 2i2y

Solution structure of the RRM of SRp20 bound to the RNA CAUC

Template:ABSTRACT PUBMED 17036044

About this Structure

2I2Y is a Single protein structure of sequence from Streptococcus sp. group g and homo sapiens. Full experimental information is available from OCA.

Reference

Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8., Hargous Y, Hautbergue GM, Tintaru AM, Skrisovska L, Golovanov AP, Stevenin J, Lian LY, Wilson SA, Allain FH, EMBO J. 2006 Nov 1;25(21):5126-37. Epub 2006 Oct 12. PMID:17036044

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