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1jxq

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[[Image:1jxq.gif|left|200px]]
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{{Seed}}
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[[Image:1jxq.png|left|200px]]
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{{STRUCTURE_1jxq| PDB=1jxq | SCENE= }}
{{STRUCTURE_1jxq| PDB=1jxq | SCENE= }}
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'''Structure of cleaved, CARD domain deleted Caspase-9'''
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===Structure of cleaved, CARD domain deleted Caspase-9===
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==Overview==
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A critical step in the induction of apoptosis is the activation of the apoptotic initiator caspase 9. We show that at its normal physiological concentration, caspase 9 is primarily an inactive monomer (zymogen), and that activity is associated with a dimeric species. At the high concentrations used for crystal formation, caspase 9 is dimeric, and the structure reveals two very different active-site conformations within each dimer. One site closely resembles the catalytically competent sites of other caspases, whereas in the second, expulsion of the "activation loop" disrupts the catalytic machinery. We propose that the inactive domain resembles monomeric caspase 9. Activation is induced by dimerization, with interactions at the dimer interface promoting reorientation of the activation loop. These observations support a model in which recruitment by Apaf-1 creates high local concentrations of caspase 9 to provide a pathway for dimer-induced activation.
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The line below this paragraph, {{ABSTRACT_PUBMED_11734640}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11734640 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11734640}}
==About this Structure==
==About this Structure==
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[[Category: Stennicke, H R.]]
[[Category: Stennicke, H R.]]
[[Category: Protease-inhibitor complex]]
[[Category: Protease-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:03:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:23:21 2008''

Revision as of 23:23, 28 July 2008

Image:1jxq.png

Template:STRUCTURE 1jxq

Structure of cleaved, CARD domain deleted Caspase-9

Template:ABSTRACT PUBMED 11734640

About this Structure

1JXQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Dimer formation drives the activation of the cell death protease caspase 9., Renatus M, Stennicke HR, Scott FL, Liddington RC, Salvesen GS, Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14250-5. PMID:11734640

Page seeded by OCA on Tue Jul 29 02:23:21 2008

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