This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1pp8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1pp8.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1pp8.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1pp8| PDB=1pp8 | SCENE= }}
{{STRUCTURE_1pp8| PDB=1pp8 | SCENE= }}
-
'''crystal structure of the T. vaginalis IBP39 Initiator binding domain (IBD) bound to the alpha-SCS Inr element'''
+
===crystal structure of the T. vaginalis IBP39 Initiator binding domain (IBD) bound to the alpha-SCS Inr element===
-
==Overview==
+
<!--
-
Transcription start site selection in eukaryotes is mediated through combinations of the TATA, initiator (Inr), and downstream promoter elements (DPE). In Trichomonas vaginalis, a parabasalian flagellate thought to represent an ancient eukaryote lineage, the Inr appears to be solely responsible for start site selection and is recognized by the initiator binding protein 39 kDa (IBP39). IBP39 contains an N-terminal Inr binding domain (IBD) connected via a flexible linker to a C-terminal domain (C domain). Here we present crystal structures of the apoIBD and IBD-Inr complexes and the C domain. The IBD structures reveal a winged-helix motif with prokaryotic and eukaryotic features and a scaffold similar to that of ETS-family proteins. The C domain structure and biochemical studies indicate that it interacts with the T. vaginalis RNAP II large subunit C-terminal domain. These data suggest that binding of IBP39 to the Inr directly recruits RNAP II and in this way initiates transcription.
+
The line below this paragraph, {{ABSTRACT_PUBMED_14622596}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 14622596 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_14622596}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: T. vaginali]]
[[Category: T. vaginali]]
[[Category: Transcription]]
[[Category: Transcription]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:19:48 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:24:59 2008''

Revision as of 23:25, 28 July 2008

Image:1pp8.png

Template:STRUCTURE 1pp8

crystal structure of the T. vaginalis IBP39 Initiator binding domain (IBD) bound to the alpha-SCS Inr element

Template:ABSTRACT PUBMED 14622596

About this Structure

1PP8 is a Single protein structure of sequence from Trichomonas vaginalis. Full crystallographic information is available from OCA.

Reference

Structural basis of core promoter recognition in a primitive eukaryote., Schumacher MA, Lau AO, Johnson PJ, Cell. 2003 Nov 14;115(4):413-24. PMID:14622596

Page seeded by OCA on Tue Jul 29 02:24:59 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pp8"
Personal tools