2v42

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{{STRUCTURE_2v42| PDB=2v42 | SCENE= }}
{{STRUCTURE_2v42| PDB=2v42 | SCENE= }}
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'''CRYSTAL STRUCTURE OF RSEB: A SENSOR FOR PERIPLASMIC STRESS RESPONSE IN E. COLI'''
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===CRYSTAL STRUCTURE OF RSEB: A SENSOR FOR PERIPLASMIC STRESS RESPONSE IN E. COLI===
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==Overview==
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An elegant network of signal transduction has evolved in the bacterial cell envelope to respond to environmental stress. It is initiated by sensing unfavourable and harmful changes in the periplasm. The stress signal is then transmitted by a controlled degradation of the transmembrane anti-sigma-factor RseA that leads to the activation of the alternative sigma factor sigma(E). The periplasmic protein RseB exerts a crucial role in modulating the stability of RseA. RseB from Escherichia coli has been crystallized and crystal structures were determined at 2.4 A and at 2.8 A resolution. The protein forms a homodimer, with the monomer composed of two domains. The large domain resembles an unclosed beta-barrel that is structurally remarkably similar to a protein family capable of binding the lipid anchor of lipoproteins. The small C-terminal domain, connected to the large domain by a partially unstructured loop, is responsible for interaction with RseA. On the basis of the structure of RseB, we suggest that it acts as a sensor of periplasmic stress with a dual functionality: it detects mislocalized lipoproteins and propagates the signal to induce the sigma(E)-response.
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(as it appears on PubMed at http://www.pubmed.gov), where 17692869 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17692869}}
==About this Structure==
==About this Structure==
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[[Category: Regulator]]
[[Category: Regulator]]
[[Category: Regulatory protein,lipoprotein binding,sensor for periplasmic stress]]
[[Category: Regulatory protein,lipoprotein binding,sensor for periplasmic stress]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:11:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:25:23 2008''

Revision as of 23:25, 28 July 2008

Image:2v42.png

Template:STRUCTURE 2v42

CRYSTAL STRUCTURE OF RSEB: A SENSOR FOR PERIPLASMIC STRESS RESPONSE IN E. COLI

Template:ABSTRACT PUBMED 17692869

About this Structure

2V42 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The structure of RseB: a sensor in periplasmic stress response of E. coli., Wollmann P, Zeth K, J Mol Biol. 2007 Sep 28;372(4):927-41. Epub 2007 Jun 19. PMID:17692869

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