1zea

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1zea.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1zea.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1zea| PDB=1zea | SCENE= }}
{{STRUCTURE_1zea| PDB=1zea | SCENE= }}
-
'''Structure of the anti-cholera toxin antibody Fab fragment TE33 in complex with a D-peptide'''
+
===Structure of the anti-cholera toxin antibody Fab fragment TE33 in complex with a D-peptide===
-
==Overview==
+
<!--
-
The structure of a complex of the anti-cholera toxin antibody TE33 Fab (fragment antibody) with the D-peptide vpGsqhyds was solved to 1.78 A resolution. The D-peptide was derived from the linear L-peptide epitope VPGSQHIDS by a stepwise transformation. Despite the very similar amino acid sequence-the only difference is a tyrosine residue in position 7-there are marked differences in the individual positions with respect to their contribution to the peptide overall affinity as ascertained by a complete substitutional analysis. This is reflected by the X-ray structure of the TE33 Fab/D-peptide complex where there is an inverted orientation of the D-peptide as compared with the known structure of a corresponding complex containing the epitope L-peptide, with the side chains establishing different contacts within the binding site of TE33. The D- and L-peptide affinities are comparable and the surface areas buried by complex formation are almost the same. Thus the antibody TE33 provides a typical example for polyspecific binding behavior of IgG family antibodies.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17712773}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17712773 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17712773}}
==About this Structure==
==About this Structure==
Line 35: Line 39:
[[Category: Polyspecificity]]
[[Category: Polyspecificity]]
[[Category: Substitution matrix]]
[[Category: Substitution matrix]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:31:12 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:29:25 2008''

Revision as of 23:29, 28 July 2008

Image:1zea.png

Template:STRUCTURE 1zea

Structure of the anti-cholera toxin antibody Fab fragment TE33 in complex with a D-peptide

Template:ABSTRACT PUBMED 17712773

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of an anti-cholera toxin antibody Fab in complex with an epitope-derived D-peptide: a case of polyspecific recognition., Scheerer P, Kramer A, Otte L, Seifert M, Wessner H, Scholz C, Krauss N, Schneider-Mergener J, Hohne W, J Mol Recognit. 2007 Jul-Aug;20(4):263-74. PMID:17712773

Page seeded by OCA on Tue Jul 29 02:29:25 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zea"
Personal tools