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1qtj

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{{STRUCTURE_1qtj| PDB=1qtj | SCENE= }}
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'''CRYSTAL STRUCTURE OF LIMULUS POLYPHEMUS SAP'''
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===CRYSTAL STRUCTURE OF LIMULUS POLYPHEMUS SAP===
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==Overview==
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C-reactive protein and serum amyloid P component are members of the pentraxin family of oligomeric serum proteins which has been conserved through evolution. In humans both have pentameric structures and both play complex roles in the immune response, C-reactive protein being the classical acute-phase reactant produced in response to tissue damage and inflammation. An invertebrate SAP-like pentraxin has not previously been identified and it has been postulated that C-reactive protein and serum amyloid P component are products of a gene duplication event within vertebrate evolution. We have isolated serum amyloid P component from the haemolymph of the phylogenetically ancient "living fossil", the horseshoe crab Limulus polyphemus and determined the three-dimensional structure by X-ray crystallography. The structure of the previously undiscovered Limulus serum amyloid P component, the first invertebrate lectin structure to be determined, reveals the pentraxin fold and a novel doubly stacked octameric ring. The crystal structure and the discovery that both prototypic pentraxins are present in Limulus raises the possibility that both were present in the common ancestors of arthropods and chordates over 500 million years ago. The impact of the results on our understanding of the origins and evolution of pentraxins and innate immunity is discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 10438598 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10438598}}
==About this Structure==
==About this Structure==
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[[Category: Pentraxin fold]]
[[Category: Pentraxin fold]]
[[Category: Physiological doubly-stacked octamer]]
[[Category: Physiological doubly-stacked octamer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:41:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:32:38 2008''

Revision as of 23:32, 28 July 2008

Image:1qtj.png

Template:STRUCTURE 1qtj

CRYSTAL STRUCTURE OF LIMULUS POLYPHEMUS SAP

Template:ABSTRACT PUBMED 10438598

About this Structure

Full crystallographic information is available from OCA.

Reference

C-reactive protein and SAP-like pentraxin are both present in Limulus polyphemus haemolymph: crystal structure of Limulus SAP., Shrive AK, Metcalfe AM, Cartwright JR, Greenhough TJ, J Mol Biol. 1999 Jul 30;290(5):997-1008. PMID:10438598

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