2d94

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{{STRUCTURE_2d94| PDB=2d94 | SCENE= }}
{{STRUCTURE_2d94| PDB=2d94 | SCENE= }}
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'''THE CONFORMATION OF THE DNA DOUBLE HELIX IN THE CRYSTAL IS DEPENDENT ON ITS ENVIRONMENT'''
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===THE CONFORMATION OF THE DNA DOUBLE HELIX IN THE CRYSTAL IS DEPENDENT ON ITS ENVIRONMENT===
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==Overview==
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Studies of the crystal structures of more than 30 synthetic DNA fragments have provided structural information about three basic forms of the double helix: A-, B- and Z-form DNA. These studies have demonstrated that the DNA double helix adopts a highly variable structure which is related to its base sequence. The extent to which such observed structures are influenced by the crystalline environment can be found by studying the same molecule in different crystalline forms. We have recently crystallized one particular oligomer in various crystal forms. Here we report the results of structural analyses of the different crystal structures and demonstrate that the DNA double helix can adopt a range of conformations in the crystalline state depending on hydration, molecular packing and temperature. These results have implications on our understanding of the influence of the environment on DNA structure, and on the modes of DNA recognition by proteins.
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The line below this paragraph, {{ABSTRACT_PUBMED_2586615}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 2586615 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2586615}}
==About this Structure==
==About this Structure==
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[[Category: A-dna]]
[[Category: A-dna]]
[[Category: Double helix]]
[[Category: Double helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:55:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:35:10 2008''

Revision as of 23:35, 28 July 2008

Image:2d94.png

Template:STRUCTURE 2d94

THE CONFORMATION OF THE DNA DOUBLE HELIX IN THE CRYSTAL IS DEPENDENT ON ITS ENVIRONMENT

Template:ABSTRACT PUBMED 2586615

About this Structure

Full crystallographic information is available from OCA.

Reference

The conformation of the DNA double helix in the crystal is dependent on its environment., Shakked Z, Guerstein-Guzikevich G, Eisenstein M, Frolow F, Rabinovich D, Nature. 1989 Nov 23;342(6248):456-60. PMID:2586615

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