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1z10

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[[Image:1z10.gif|left|200px]]
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{{STRUCTURE_1z10| PDB=1z10 | SCENE= }}
{{STRUCTURE_1z10| PDB=1z10 | SCENE= }}
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'''Crystal Structure of Human Microsomal P450 2A6 with Coumarin Bound'''
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===Crystal Structure of Human Microsomal P450 2A6 with Coumarin Bound===
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==Overview==
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Human microsomal cytochrome P450 2A6 (CYP2A6) contributes extensively to nicotine detoxication but also activates tobacco-specific procarcinogens to mutagenic products. The CYP2A6 structure shows a compact, hydrophobic active site with one hydrogen bond donor, Asn297, that orients coumarin for regioselective oxidation. The inhibitor methoxsalen effectively fills the active site cavity without substantially perturbing the structure. The structure should aid the design of inhibitors to reduce smoking and tobacco-related cancers.
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(as it appears on PubMed at http://www.pubmed.gov), where 16086027 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16086027}}
==About this Structure==
==About this Structure==
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[[Category: P450]]
[[Category: P450]]
[[Category: P450 2a6]]
[[Category: P450 2a6]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:03:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:38:03 2008''

Revision as of 23:38, 28 July 2008

Image:1z10.png

Template:STRUCTURE 1z10

Crystal Structure of Human Microsomal P450 2A6 with Coumarin Bound

Template:ABSTRACT PUBMED 16086027

About this Structure

1Z10 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen., Yano JK, Hsu MH, Griffin KJ, Stout CD, Johnson EF, Nat Struct Mol Biol. 2005 Sep;12(9):822-3. Epub 2005 Aug 7. PMID:16086027

Page seeded by OCA on Tue Jul 29 02:38:03 2008

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