2qbp

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{{STRUCTURE_2qbp| PDB=2qbp | SCENE= }}
{{STRUCTURE_2qbp| PDB=2qbp | SCENE= }}
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'''Crystal structure of ptp1b-inhibitor complex'''
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===Crystal structure of ptp1b-inhibitor complex===
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==Overview==
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Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of the insulin and leptin receptor pathways and thus an attractive therapeutic target for diabetes and obesity. Starting with a high micromolar lead compound, structure-based optimization of novel PTP1B inhibitors by extension of the molecule from the enzyme active site into the second phosphotyrosine binding site is described. Medicinal chemistry, guided by X-ray complex structure and molecular modeling, has yielded low nanomolar PTP1B inhibitors in an efficient manner. Compounds from this chemical series were found to be actively transported into hepatocytes. This active uptake into target tissues could be one of the possible avenues to overcome the poor membrane permeability of PTP1B inhibitors.
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(as it appears on PubMed at http://www.pubmed.gov), where 17705360 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17705360}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]
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Revision as of 23:38, 28 July 2008

Image:2qbp.png

Template:STRUCTURE 2qbp

Crystal structure of ptp1b-inhibitor complex

Template:ABSTRACT PUBMED 17705360

About this Structure

2QBP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site., Wilson DP, Wan ZK, Xu WX, Kirincich SJ, Follows BC, Joseph-McCarthy D, Foreman K, Moretto A, Wu J, Zhu M, Binnun E, Zhang YL, Tam M, Erbe DV, Tobin J, Xu X, Leung L, Shilling A, Tam SY, Mansour TS, Lee J, J Med Chem. 2007 Sep 20;50(19):4681-98. Epub 2007 Aug 17. PMID:17705360

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