1qbp

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{{STRUCTURE_1qbp| PDB=1qbp | SCENE= }}
{{STRUCTURE_1qbp| PDB=1qbp | SCENE= }}
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'''CRYSTAL STRUCTURE OF A BROMINATED RNA HELIX WITH FOUR MISMATCHED BASE PAIRS'''
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===CRYSTAL STRUCTURE OF A BROMINATED RNA HELIX WITH FOUR MISMATCHED BASE PAIRS===
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==Overview==
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The X-ray crystal structure of a brominated RNA helix with four mismatched base pairs and sequence r(UG(Br)C(Br)CAGUUCGCUGGC)(2) was determined to 2.1 A using the methods of multiwavelength anomalous diffraction (MAD) applied to the bromine K-absorption edge. There are three molecules in the asymmetric unit with unique crystal-packing environments, revealing true conformational variability at high resolution for this sequence. The structure shows that the sequence itself does not define a consistent pattern of solvent molecules, with the exception of the mismatched base pairs, implying that specific RNA-protein interactions would occur only with the nucleotides. There are a number of significant tertiary interactions, some of which are a result of the brominated base pairs and others that are directly mediated by the RNA 2' hydroxyl groups. The mismatched base pairs exhibit a solvent network as well as a stacking pattern with their nearest neighbors that validate previous thermodynamic analysis.
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(as it appears on PubMed at http://www.pubmed.gov), where 10504226 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10504226}}
==About this Structure==
==About this Structure==
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[[Category: Brominated cytosine]]
[[Category: Brominated cytosine]]
[[Category: Mismatched base pair]]
[[Category: Mismatched base pair]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:06:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:42:38 2008''

Revision as of 23:42, 28 July 2008

Image:1qbp.png

Template:STRUCTURE 1qbp

CRYSTAL STRUCTURE OF A BROMINATED RNA HELIX WITH FOUR MISMATCHED BASE PAIRS

Template:ABSTRACT PUBMED 10504226

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of a brominated RNA helix with four mismatched base pairs: An investigation into RNA conformational variability., Anderson AC, O'Neil RH, Filman DJ, Frederick CA, Biochemistry. 1999 Sep 28;38(39):12577-85. PMID:10504226

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