2q5l

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{{STRUCTURE_2q5l| PDB=2q5l | SCENE= }}
{{STRUCTURE_2q5l| PDB=2q5l | SCENE= }}
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'''X-ray structure of phenylpyruvate decarboxylase in complex with 2-(1-hydroxyethyl)-3-deaza-ThDP'''
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===X-ray structure of phenylpyruvate decarboxylase in complex with 2-(1-hydroxyethyl)-3-deaza-ThDP===
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==Overview==
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Thiamine diphosphate-dependent enzymes are involved in a wide variety of metabolic pathways. The molecular mechanism behind active site communication and substrate activation, observed in some of these enzymes, has since long been an area of debate. Here, we report the crystal structures of a phenylpyruvate decarboxylase in complex with its substrates and a covalent reaction intermediate analogue. These structures reveal the regulatory site and unveil the mechanism of allosteric substrate activation. This signal transduction relies on quaternary structure reorganizations, domain rotations, and a pathway of local conformational changes that are relayed from the regulatory site to the active site. The current findings thus uncover the molecular mechanism by which the binding of a substrate in the regulatory site is linked to the mounting of the catalytic machinery in the active site in this thiamine diphosphate-dependent enzyme.
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The line below this paragraph, {{ABSTRACT_PUBMED_17905741}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17905741 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17905741}}
==About this Structure==
==About this Structure==
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[[Category: Open active site loop]]
[[Category: Open active site loop]]
[[Category: Thiamine diphosphate]]
[[Category: Thiamine diphosphate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:24:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:43:07 2008''

Revision as of 23:43, 28 July 2008

Image:2q5l.png

Template:STRUCTURE 2q5l

X-ray structure of phenylpyruvate decarboxylase in complex with 2-(1-hydroxyethyl)-3-deaza-ThDP

Template:ABSTRACT PUBMED 17905741

About this Structure

2Q5L is a Single protein structure of sequence from Azospirillum brasilense. Full crystallographic information is available from OCA.

Reference

Molecular mechanism of allosteric substrate activation in a thiamine diphosphate-dependent decarboxylase., Versees W, Spaepen S, Wood MD, Leeper FJ, Vanderleyden J, Steyaert J, J Biol Chem. 2007 Nov 30;282(48):35269-78. Epub 2007 Sep 28. PMID:17905741

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