2hcb

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{{STRUCTURE_2hcb| PDB=2hcb | SCENE= }}
{{STRUCTURE_2hcb| PDB=2hcb | SCENE= }}
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'''Structure of AMPPCP-bound DnaA from Aquifex aeolicus'''
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===Structure of AMPPCP-bound DnaA from Aquifex aeolicus===
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==Overview==
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In bacteria, the initiation of replication is controlled by DnaA, a member of the ATPases associated with various cellular activities (AAA+) protein superfamily. ATP binding allows DnaA to transition from a monomeric state into a large oligomeric complex that remodels replication origins, triggers duplex melting and facilitates replisome assembly. The crystal structure of AMP-PCP-bound DnaA reveals a right-handed superhelix defined by specific protein-ATP interactions. The observed quaternary structure of DnaA, along with topology footprint assays, indicates that a right-handed DNA wrap is formed around the initiation nucleoprotein complex. This model clarifies how DnaA engages and unwinds bacterial origins and suggests that additional, regulatory AAA+ proteins engage DnaA at filament ends. Eukaryotic and archaeal initiators also have the structural elements that promote open-helix formation, indicating that a spiral, open-ring AAA+ assembly forms the core element of initiators in all domains of life.
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(as it appears on PubMed at http://www.pubmed.gov), where 16829961 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16829961}}
==About this Structure==
==About this Structure==
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[[Category: Aaa+ atpase]]
[[Category: Aaa+ atpase]]
[[Category: Helix-turn-helix]]
[[Category: Helix-turn-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:07:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:46:19 2008''

Revision as of 23:46, 28 July 2008

Image:2hcb.png

Template:STRUCTURE 2hcb

Structure of AMPPCP-bound DnaA from Aquifex aeolicus

Template:ABSTRACT PUBMED 16829961

About this Structure

2HCB is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.

Reference

Structural basis for ATP-dependent DnaA assembly and replication-origin remodeling., Erzberger JP, Mott ML, Berger JM, Nat Struct Mol Biol. 2006 Aug;13(8):676-83. Epub 2006 Jul 9. PMID:16829961

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