1r1a

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{{STRUCTURE_1r1a| PDB=1r1a | SCENE= }}
{{STRUCTURE_1r1a| PDB=1r1a | SCENE= }}
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'''CRYSTAL STRUCTURE OF HUMAN RHINOVIRUS SEROTYPE 1A (HRV1A)'''
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===CRYSTAL STRUCTURE OF HUMAN RHINOVIRUS SEROTYPE 1A (HRV1A)===
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==Overview==
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The structure of human rhinovirus 1A (HRV1A) has been determined to 3.2 A resolution using phase refinement and extension by symmetry averaging starting with phases at 5 A resolution calculated from the known human rhinovirus 14 (HRV14) structure. The polypeptide backbone structures of HRV1A and HRV14 are similar, but the exposed surfaces are rather different. Differential charge distribution of amino acid residues in the "canyon", the putative receptor binding site, provides a possible explanation for the difference in minor versus major receptor group specificities, represented by HRV1A and HRV14, respectively. The hydrophobic pocket in VP1, into which antiviral compounds bind, is in an "open" conformation similar to that observed in drug-bound HRV14. Drug binding in HRV1A does not induce extensive conformational changes, in contrast to the case of HRV14.
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(as it appears on PubMed at http://www.pubmed.gov), where 2555523 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2555523}}
==About this Structure==
==About this Structure==
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[[Category: Icosahedral virus]]
[[Category: Icosahedral virus]]
[[Category: Rhinovirus coat protein]]
[[Category: Rhinovirus coat protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:57:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:49:32 2008''

Revision as of 23:49, 28 July 2008

Image:1r1a.png

Template:STRUCTURE 1r1a

CRYSTAL STRUCTURE OF HUMAN RHINOVIRUS SEROTYPE 1A (HRV1A)

Template:ABSTRACT PUBMED 2555523

About this Structure

1R1A is a Protein complex structure of sequences from Human rhinovirus 1a. Full crystallographic information is available from OCA.

Reference

Crystal structure of human rhinovirus serotype 1A (HRV1A)., Kim SS, Smith TJ, Chapman MS, Rossmann MC, Pevear DC, Dutko FJ, Felock PJ, Diana GD, McKinlay MA, J Mol Biol. 1989 Nov 5;210(1):91-111. PMID:2555523

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