1xkw

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{{STRUCTURE_1xkw| PDB=1xkw | SCENE= }}
{{STRUCTURE_1xkw| PDB=1xkw | SCENE= }}
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'''Pyochelin outer membrane receptor FptA from Pseudomonas aeruginosa'''
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===Pyochelin outer membrane receptor FptA from Pseudomonas aeruginosa===
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==Overview==
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Pyochelin is a siderophore and virulence factor common to Burkholderia cepacia and several Pseudomonas strains. We describe at 2.0 A resolution the crystal structure of the pyochelin outer membrane receptor FptA bound to the iron-pyochelin isolated from Pseudomonas aeruginosa. One pyochelin molecule bound to iron is found in the protein structure, providing the first three-dimensional structure at the atomic level of this siderophore. The pyochelin molecule provides a tetra-dentate coordination of iron, while the remaining bi-dentate coordination is ensured by another molecule not specifically recognized by the protein. The overall structure of the pyochelin receptor is typical of the TonB-dependent transporter superfamily, which uses the proton motive force from the cytoplasmic membrane through the TonB-ExbB-ExbD energy transducing complex to transport ferric ions across the bacterial outer membrane: a transmembrane 22 beta-stranded barrel occluded by a N-terminal domain that contains a mixed four-stranded beta-sheet. The N-terminal TonB box is disordered in two crystal forms, and loop L8 is found to point towards the iron-pyochelin complex, suggesting that the receptor is in a transport-competent conformation.
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(as it appears on PubMed at http://www.pubmed.gov), where 16139844 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16139844}}
==About this Structure==
==About this Structure==
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[[Category: Pattus, F.]]
[[Category: Pattus, F.]]
[[Category: Tonb dependent receptor]]
[[Category: Tonb dependent receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:09:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:50:14 2008''

Revision as of 23:50, 28 July 2008

Image:1xkw.png

Template:STRUCTURE 1xkw

Pyochelin outer membrane receptor FptA from Pseudomonas aeruginosa

Template:ABSTRACT PUBMED 16139844

About this Structure

1XKW is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Crystal structure at high resolution of ferric-pyochelin and its membrane receptor FptA from Pseudomonas aeruginosa., Cobessi D, Celia H, Pattus F, J Mol Biol. 2005 Sep 30;352(4):893-904. PMID:16139844

Page seeded by OCA on Tue Jul 29 02:50:14 2008

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