2fkd

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{{STRUCTURE_2fkd| PDB=2fkd | SCENE= }}
{{STRUCTURE_2fkd| PDB=2fkd | SCENE= }}
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'''Crystal Structure of the C-terminal domain of Bacteriophage 186 repressor'''
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===Crystal Structure of the C-terminal domain of Bacteriophage 186 repressor===
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==Overview==
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Bacteriophage lambda is a paradigm for understanding the role of cooperativity in gene regulation. Comparison of the regulatory regions of lambda and the unrelated temperate bacteriophage 186 provides insight into alternate ways to assemble functional genetic switches. The structure of the C-terminal domain of the 186 repressor, determined at 2.7 A resolution, reveals an unusual heptamer of dimers, consistent with presented genetic studies. In addition, the structure of a cooperativity mutant of the full-length 186 repressor, identified by genetic screens, was solved to 1.95 A resolution. These structures provide a molecular basis for understanding lysogenic regulation in 186. Whereas the overall fold of the 186 and lambda repressor monomers is remarkably similar, the way the two repressors cooperatively assemble is quite different and explains in part the differences in their regulatory activity.
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(as it appears on PubMed at http://www.pubmed.gov), where 16507359 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16507359}}
==About this Structure==
==About this Structure==
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[[Category: Regulation]]
[[Category: Regulation]]
[[Category: Repressor]]
[[Category: Repressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:50:26 2008''

Revision as of 23:50, 28 July 2008

Image:2fkd.png

Template:STRUCTURE 2fkd

Crystal Structure of the C-terminal domain of Bacteriophage 186 repressor

Template:ABSTRACT PUBMED 16507359

About this Structure

2FKD is a Single protein structure of sequence from Enterobacteria phage 186. Full crystallographic information is available from OCA.

Reference

The structural basis of cooperative regulation at an alternate genetic switch., Pinkett HW, Shearwin KE, Stayrook S, Dodd IB, Burr T, Hochschild A, Egan JB, Lewis M, Mol Cell. 2006 Mar 3;21(5):605-15. PMID:16507359

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