We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1u8d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1u8d.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1u8d.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1u8d| PDB=1u8d | SCENE= }}
{{STRUCTURE_1u8d| PDB=1u8d | SCENE= }}
-
'''Guanine riboswitch bound to hypoxanthine'''
+
===Guanine riboswitch bound to hypoxanthine===
-
==Overview==
+
<!--
-
Riboswitches are genetic regulatory elements found in the 5' untranslated region of messenger RNA that act in the absence of protein cofactors. They are broadly distributed across bacteria and account for the regulation of more than 2% of all genes in Bacillus subtilis, underscoring their importance in the control of cellular metabolism. The 5' untranslated region of many mRNAs of genes involved in purine metabolism and transport contain a guanine-responsive riboswitch that directly binds guanine, hypoxanthine or xanthine to terminate transcription. Here we report the crystal structure at 1.95 A resolution of the purine-binding domain of the guanine riboswitch from the xpt-pbuX operon of B. subtilis bound to hypoxanthine, a prevalent metabolite in the bacterial purine salvage pathway. This structure reveals a complex RNA fold involving several phylogenetically conserved nucleotides that create a binding pocket that almost completely envelops the ligand. Hypoxanthine functions to stabilize this structure and to promote the formation of a downstream transcriptional terminator element, thereby providing a mechanism for directly repressing gene expression in response to an increase in intracellular concentrations of metabolite.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15549109}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15549109 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15549109}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Mrna]]
[[Category: Mrna]]
[[Category: Rna-ligand complex]]
[[Category: Rna-ligand complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:53:22 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:55:51 2008''

Revision as of 23:55, 28 July 2008

Image:1u8d.png

Template:STRUCTURE 1u8d

Guanine riboswitch bound to hypoxanthine

Template:ABSTRACT PUBMED 15549109

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of a natural guanine-responsive riboswitch complexed with the metabolite hypoxanthine., Batey RT, Gilbert SD, Montange RK, Nature. 2004 Nov 18;432(7015):411-5. PMID:15549109

Page seeded by OCA on Tue Jul 29 02:55:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1u8d"
Personal tools