2oif

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[[Image:2oif.jpg|left|200px]]
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{{Seed}}
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[[Image:2oif.png|left|200px]]
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{{STRUCTURE_2oif| PDB=2oif | SCENE= }}
{{STRUCTURE_2oif| PDB=2oif | SCENE= }}
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'''The crystal structure of ferric cyanide bound barley hexacoordinate hemoglobin.'''
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===The crystal structure of ferric cyanide bound barley hexacoordinate hemoglobin.===
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==Overview==
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The evolution of oxygen transport hemoglobins occurred on at least two independent occasions. The earliest event led to myoglobin and red blood cell hemoglobin in animals. In plants, oxygen transport "leghemoglobins" evolved much more recently. In both events, pentacoordinate heme sites capable of inert oxygen transfer evolved from hexacoordinate hemoglobins that have unrelated functions. High sequence homology between hexacoordinate and pentacoordinate hemoglobins in plants has poised them for potential structural analysis leading to a molecular understanding of this important evolutionary event. However, the lack of a plant hexacoordinate hemoglobin structure in the exogenously ligand-bound form has prevented such comparison. Here we report the crystal structure of the cyanide-bound hexacoordinate hemoglobin from barley. This presents the first opportunity to examine conformational changes in plant hexacoordinate hemoglobins upon exogenous ligand binding, and reveals structural mechanisms for stabilizing the high-energy pentacoordinate heme conformation critical to the evolution of reversible oxygen binding hemoglobins.
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(as it appears on PubMed at http://www.pubmed.gov), where 17560601 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17560601}}
==About this Structure==
==About this Structure==
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[[Category: Oxygen transport]]
[[Category: Oxygen transport]]
[[Category: Symbiotic]]
[[Category: Symbiotic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:59:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:03:14 2008''

Revision as of 00:03, 29 July 2008

Image:2oif.png

Template:STRUCTURE 2oif

The crystal structure of ferric cyanide bound barley hexacoordinate hemoglobin.

Template:ABSTRACT PUBMED 17560601

About this Structure

2OIF is a Single protein structure of sequence from Hordeum vulgare. Full crystallographic information is available from OCA.

Reference

Plant hemoglobins: a molecular fossil record for the evolution of oxygen transport., Hoy JA, Robinson H, Trent JT 3rd, Kakar S, Smagghe BJ, Hargrove MS, J Mol Biol. 2007 Aug 3;371(1):168-79. Epub 2007 May 18. PMID:17560601

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