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2ait

From Proteopedia

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[[Image:2ait.gif|left|200px]]
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{{Seed}}
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[[Image:2ait.png|left|200px]]
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{{STRUCTURE_2ait| PDB=2ait | SCENE= }}
{{STRUCTURE_2ait| PDB=2ait | SCENE= }}
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'''DETERMINATION OF THE COMPLETE THREE-DIMENSIONAL STRUCTURE OF THE ALPHA-AMYLASE INHIBITOR TENDAMISTAT IN AQUEOUS SOLUTION BY NUCLEAR MAGNETIC RESONANCE AND DISTANCE GEOMETRY'''
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===DETERMINATION OF THE COMPLETE THREE-DIMENSIONAL STRUCTURE OF THE ALPHA-AMYLASE INHIBITOR TENDAMISTAT IN AQUEOUS SOLUTION BY NUCLEAR MAGNETIC RESONANCE AND DISTANCE GEOMETRY===
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==Overview==
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The complete three-dimensional structure of the alpha-amylase inhibitor Tendamistat in aqueous solution was determined by 1H nuclear magnetic resonance and distance geometry calculations using the program DISMAN. Compared to an earlier, preliminary determination of the polypeptide backbone conformation, stereo-specific assignments were obtained for 41 of the 89 prochiral groups in the protein, and a much more extensive set of experimental constraints was collected, including 842 distance constraints from nuclear Overhauser effects and over 100 supplementary constraints from spin-spin coupling constants and the identification of intramolecular hydrogen bonds. The complete protein molecule, including the amino acid side-chains is characterized by a group of nine structures corresponding to the results of the nine DISMAN calculations with minimal residual error functions. The average of the pairwise minimal root-mean-square distances among these nine structures is 0.85 A for the polypeptide backbone, and 1.52 A for all the heavy atoms. The procedures used for the structure determination are described and a detailed analysis is presented of correlations between the experimental input data and the precision of the structure determination.
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The line below this paragraph, {{ABSTRACT_PUBMED_3265733}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 3265733 is the PubMed ID number.
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{{ABSTRACT_PUBMED_3265733}}
==About this Structure==
==About this Structure==
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2AIT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_tendae Streptomyces tendae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIT OCA].
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2AIT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_tendae Streptomyces tendae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIT OCA].
==Reference==
==Reference==
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[[Category: Wuthrich, K.]]
[[Category: Wuthrich, K.]]
[[Category: Alpha-amylase inhibitor]]
[[Category: Alpha-amylase inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:06:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:04:53 2008''

Revision as of 00:04, 29 July 2008

Image:2ait.png

Template:STRUCTURE 2ait

DETERMINATION OF THE COMPLETE THREE-DIMENSIONAL STRUCTURE OF THE ALPHA-AMYLASE INHIBITOR TENDAMISTAT IN AQUEOUS SOLUTION BY NUCLEAR MAGNETIC RESONANCE AND DISTANCE GEOMETRY

Template:ABSTRACT PUBMED 3265733

About this Structure

2AIT is a Single protein structure of sequence from Streptomyces tendae. Full experimental information is available from OCA.

Reference

Determination of the complete three-dimensional structure of the alpha-amylase inhibitor tendamistat in aqueous solution by nuclear magnetic resonance and distance geometry., Kline AD, Braun W, Wuthrich K, J Mol Biol. 1988 Dec 5;204(3):675-724. PMID:3265733

Page seeded by OCA on Tue Jul 29 03:04:53 2008

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