1wm7

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{{STRUCTURE_1wm7| PDB=1wm7 | SCENE= }}
{{STRUCTURE_1wm7| PDB=1wm7 | SCENE= }}
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'''Solution Structure of BmP01 from the Venom of Scorpion Buthus martensii Karsch, 9 structures'''
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===Solution Structure of BmP01 from the Venom of Scorpion Buthus martensii Karsch, 9 structures===
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==Overview==
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From the venom of scorpion Buthus martensii Karsch,a short peptide (BmP01, 29 amino acid residues) was isolated and characterized as previously reported (Lebren, R. R., et al. (1997) Eur. J. Biochem. 245, 457-464). It was shown to reduce 33% outward K(+) channel (hippocampal neurons) currents at 10 microM. The solution structure of BmP01 was determined by 2D (1)H NMR spectroscopy. The NOEs, coupling constants, and H-D exchange obtained from NMR spectroscopy were used in structural calculations. The conformation of BmP01 is composed of a short alpha-helix (Cys 3-Thr 12) and a two-stranded antiparallel beta-sheet (Ala 15-Asp 20 and Lys 23-Pro 28). There are three disulfide bridges (Cys 3-Cys 19, Cys 6-Cys 24 and Cys 10-Cys 26) connecting the alpha-helix and beta-sheet. Asp 20 to Lys 23 form a type II turn linking the two strands. Structural and electrostatic potential comparison between BmP01 and its analogues are also presented.
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(as it appears on PubMed at http://www.pubmed.gov), where 11027603 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11027603}}
==About this Structure==
==About this Structure==
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1WM7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WM7 OCA].
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1WM7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WM7 OCA].
==Reference==
==Reference==
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[[Category: Wu, H.]]
[[Category: Wu, H.]]
[[Category: Alpha/beta scaffold]]
[[Category: Alpha/beta scaffold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:52:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:05:10 2008''

Revision as of 00:05, 29 July 2008

Image:1wm7.png

Template:STRUCTURE 1wm7

Solution Structure of BmP01 from the Venom of Scorpion Buthus martensii Karsch, 9 structures

Template:ABSTRACT PUBMED 11027603

About this Structure

1WM7 is a Single protein structure of sequence from Mesobuthus martensii. Full experimental information is available from OCA.

Reference

Solution structure of BmP01 from the venom of scorpion Buthus martensii Karsch., Wu G, Li Y, Wei D, He F, Jiang S, Hu G, Wu H, Biochem Biophys Res Commun. 2000 Oct 5;276(3):1148-54. PMID:11027603

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