1t6e

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{{STRUCTURE_1t6e| PDB=1t6e | SCENE= }}
{{STRUCTURE_1t6e| PDB=1t6e | SCENE= }}
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'''Crystal Structure of the Triticum aestivum xylanase inhibitor I'''
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===Crystal Structure of the Triticum aestivum xylanase inhibitor I===
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==Overview==
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Plants developed a diverse battery of defense mechanisms in response to continual challenges by a broad spectrum of pathogenic microorganisms. Their defense arsenal includes inhibitors of cell wall-degrading enzymes, which hinder a possible invasion and colonization by antagonists. The structure of Triticum aestivum xylanase inhibitor-I (TAXI-I), a first member of potent TAXI-type inhibitors of fungal and bacterial family 11 xylanases, has been determined to 1.7-A resolution. Surprisingly, TAXI-I displays structural homology with the pepsin-like family of aspartic proteases but is proteolytically nonfunctional, because one or more residues of the essential catalytical triad are absent. The structure of the TAXI-I.Aspergillus niger xylanase I complex, at a resolution of 1.8 A, illustrates the ability of tight binding and inhibition with subnanomolar affinity and indicates the importance of the C-terminal end for the differences in xylanase specificity among different TAXI-type inhibitors.
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{{ABSTRACT_PUBMED_15166216}}
==About this Structure==
==About this Structure==
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[[Category: Sansen, S.]]
[[Category: Sansen, S.]]
[[Category: Two beta-barrel domain structure]]
[[Category: Two beta-barrel domain structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:05:28 2008''

Revision as of 00:05, 29 July 2008

Image:1t6e.png

Template:STRUCTURE 1t6e

Crystal Structure of the Triticum aestivum xylanase inhibitor I

Template:ABSTRACT PUBMED 15166216

About this Structure

1T6E is a Single protein structure of sequence from Triticum aestivum. Full crystallographic information is available from OCA.

Reference

Structural basis for inhibition of Aspergillus niger xylanase by triticum aestivum xylanase inhibitor-I., Sansen S, De Ranter CJ, Gebruers K, Brijs K, Courtin CM, Delcour JA, Rabijns A, J Biol Chem. 2004 Aug 20;279(34):36022-8. Epub 2004 May 27. PMID:15166216

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