1zlc

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[[Image:1zlc.gif|left|200px]]
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{{Seed}}
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[[Image:1zlc.png|left|200px]]
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{{STRUCTURE_1zlc| PDB=1zlc | SCENE= }}
{{STRUCTURE_1zlc| PDB=1zlc | SCENE= }}
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'''Solution Conformation of alpha-conotoxin PIA'''
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===Solution Conformation of alpha-conotoxin PIA===
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==Overview==
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alpha-Conotoxin PIA is a novel nicotinic acetylcholine receptor (nAChR) antagonist isolated from Conus purpurascens that targets nAChR subtypes containing alpha6 and alpha3 subunits. alpha-conotoxin PIA displays 75-fold higher affinity for rat alpha6/alpha3beta2beta3 nAChRs than for rat alpha3beta2 nAChRs. We have determined the three-dimensional structure of alpha-conotoxin PIA by nuclear magnetic resonance spectroscopy. The alpha-conotoxin PIA has an "omega-shaped" overall topology as other alpha4/7 subfamily conotoxins. Yet, unlike other neuronally targeted alpha4/7-conotoxins, its N-terminal tail Arg1-Asp2-Pro3 protrudes out of its main molecular body because Asp2-Pro3-Cys4-Cys5 forms a stable type I beta-turn. In addition, a kink introduced by Pro15 in the second loop of this toxin provides a distinct steric and electrostatic environment from those in alpha-conotoxins MII and GIC. By comparing the structure of alpha-conotoxin PIA with other functionally related alpha-conotoxins we suggest structural features in alpha-conotoxin PIA that may be associated with its unique receptor recognition profile.
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(as it appears on PubMed at http://www.pubmed.gov), where 16289101 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16289101}}
==About this Structure==
==About this Structure==
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1ZLC is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLC OCA].
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1ZLC is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLC OCA].
==Reference==
==Reference==
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[[Category: C-terminal amidation]]
[[Category: C-terminal amidation]]
[[Category: Two disulfide bond]]
[[Category: Two disulfide bond]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:45:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:11:05 2008''

Revision as of 00:11, 29 July 2008

Image:1zlc.png

Template:STRUCTURE 1zlc

Solution Conformation of alpha-conotoxin PIA

Template:ABSTRACT PUBMED 16289101

About this Structure

1ZLC is a Single protein structure. Full experimental information is available from OCA.

Reference

Solution structure of alpha-conotoxin PIA, a novel antagonist of alpha6 subunit containing nicotinic acetylcholine receptors., Chi SW, Lee SH, Kim DH, Kim JS, Olivera BM, McIntosh JM, Han KH, Biochem Biophys Res Commun. 2005 Dec 30;338(4):1990-7. Epub 2005 Nov 7. PMID:16289101

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