1yto

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[[Image:1yto.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1yto| PDB=1yto | SCENE= }}
{{STRUCTURE_1yto| PDB=1yto | SCENE= }}
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'''Crystal Structure of Gly19 deletion Mutant of Human Acidic Fibroblast Growth Factor'''
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===Crystal Structure of Gly19 deletion Mutant of Human Acidic Fibroblast Growth Factor===
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==Overview==
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Human acidic fibroblast growth factor (FGF-1) is a member of the beta-trefoil superfold, a protein architecture that exhibits a characteristic threefold axis of structural symmetry. FGF-1 contains 11 beta-turns, the majority being type I 3:5; however, a type I 4:6 turn is also found at three symmetry-related locations. The relative uniqueness of the type I 4:6 turn in the FGF-1 structure suggests it may play a key role in the stability, folding, or function of the protein. To test this hypothesis a series of deletion mutations were constructed, the aim of which was to convert existing type I 4:6 turns at two locations into type I 3:5 turns. The results show it is possible to successfully substitute the type I 4:6 turn by a type I 3:5 turn with minimal impact upon protein stability or folding. Thus, these different turn structures, even though they differ in length, exhibit similar energetic properties. Additional sequence swapping mutations within the introduced type I 3:5 turns suggests that the turn sequence primarily affects stability but not turn structure (which appears dictated primarily by the local environment). Although the results suggest that a stable, foldable beta-trefoil protein may be designed utilizing a single turn type (type I 3:5), a type I 4:6 turn at turn 1 of FGF-1 appears essential for efficient mitogenic function.
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The line below this paragraph, {{ABSTRACT_PUBMED_16355415}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16355415 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16355415}}
==About this Structure==
==About this Structure==
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[[Category: Lee, J.]]
[[Category: Lee, J.]]
[[Category: Beta-trefoil]]
[[Category: Beta-trefoil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:46:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:11:10 2008''

Revision as of 00:11, 29 July 2008

Image:1yto.png

Template:STRUCTURE 1yto

Crystal Structure of Gly19 deletion Mutant of Human Acidic Fibroblast Growth Factor

Template:ABSTRACT PUBMED 16355415

About this Structure

1YTO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Conversion of type I 4:6 to 3:5 beta-turn types in human acidic fibroblast growth factor: effects upon structure, stability, folding, and mitogenic function., Lee J, Dubey VK, Somasundaram T, Blaber M, Proteins. 2006 Mar 15;62(3):686-97. PMID:16355415

Page seeded by OCA on Tue Jul 29 03:11:10 2008

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