2fip

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[[Image:2fip.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2fip| PDB=2fip | SCENE= }}
{{STRUCTURE_2fip| PDB=2fip | SCENE= }}
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'''Phage phi29 transcription regulator p4'''
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===Phage phi29 transcription regulator p4===
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==Overview==
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Protein p4 affects the transcriptional switch that divides bacteriophage phi29 infection in early and late phases. The synthesis of DNA replication proteins and p4 takes place in the early phase, while structural, morphogenesis, and lysis proteins are synthesized in the late phase. Transcriptional switch by p4 is achieved by activating the late promoter A3 and repressing the early promoters A2b and A2c. The crystal structure of p4 alone and in complex with a 41 bp DNA, including the A3 promoter binding site, helps us to understand how the phage cycle is controlled. Protein p4 has a unique alpha/beta fold that includes a DNA recognition motif consisting of two N-terminal beta turn substructures, or N-hooks, located at the tips of an elongated protein homodimer. The two N-hooks enter the major groove of the double helix, establishing base-specific contacts. A high DNA curvature allows p4 N-hooks to reach two major groove areas three helical turns apart, like a bow and its string.
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(as it appears on PubMed at http://www.pubmed.gov), where 16600871 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16600871}}
==About this Structure==
==About this Structure==
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[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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Revision as of 00:12, 29 July 2008

Image:2fip.png

Template:STRUCTURE 2fip

Phage phi29 transcription regulator p4

Template:ABSTRACT PUBMED 16600871

About this Structure

2FIP is a Single protein structure of sequence from Bacillus phage phi29. Full crystallographic information is available from OCA.

Reference

The structure of phage phi29 transcription regulator p4-DNA complex reveals an N-hook motif for DNA., Badia D, Camacho A, Perez-Lago L, Escandon C, Salas M, Coll M, Mol Cell. 2006 Apr 7;22(1):73-81. PMID:16600871

Page seeded by OCA on Tue Jul 29 03:12:55 2008

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