1n3o

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[[Image:1n3o.gif|left|200px]]
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{{Seed}}
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[[Image:1n3o.png|left|200px]]
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{{STRUCTURE_1n3o| PDB=1n3o | SCENE= }}
{{STRUCTURE_1n3o| PDB=1n3o | SCENE= }}
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'''Pterocarcpus angolensis lectin in complex with alpha-methyl glucose'''
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===Pterocarcpus angolensis lectin in complex with alpha-methyl glucose===
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==Overview==
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The crystal structure of the Man/Glc-specific seed lectin from Pterocarpus angolensis was determined in complex with methyl-alpha-d-glucose, sucrose, and turanose. The carbohydrate binding site contains a classic Man/Glc type specificity loop. Its metal binding loop on the other hand is of the long type, different from what is observed in other Man/Glc-specific legume lectins. Glucose binding in the primary binding site is reminiscent of the glucose complexes of concanavalin A and lentil lectin. Sucrose is found to be bound in a conformation similar as seen in the binding site of lentil lectin. A direct hydrogen bond between Ser-137(OG) to Fru(O2) in Pterocarpus angolensis lectin replaces a water-mediated interaction in the equivalent complex of lentil lectin. In the turanose complex, the binding site of the first molecule in the asymmetric unit contains the alphaGlc1-3betaFruf form of furanose while the second molecule contains the alphaGlc1-3betaFrup form in its binding site.
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The line below this paragraph, {{ABSTRACT_PUBMED_12595543}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12595543 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12595543}}
==About this Structure==
==About this Structure==
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[[Category: Glucose]]
[[Category: Glucose]]
[[Category: Lectin]]
[[Category: Lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:03:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:16:36 2008''

Revision as of 00:16, 29 July 2008

Image:1n3o.png

Template:STRUCTURE 1n3o

Pterocarcpus angolensis lectin in complex with alpha-methyl glucose

Template:ABSTRACT PUBMED 12595543

About this Structure

1N3O is a Single protein structure of sequence from Pterocarpus angolensis. Full crystallographic information is available from OCA.

Reference

Crystal structure of Pterocarpus angolensis lectin in complex with glucose, sucrose, and turanose., Loris R, Imberty A, Beeckmans S, Van Driessche E, Read JS, Bouckaert J, De Greve H, Buts L, Wyns L, J Biol Chem. 2003 May 2;278(18):16297-303. Epub 2003 Feb 19. PMID:12595543

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