2oi4

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[[Image:2oi4.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2oi4| PDB=2oi4 | SCENE= }}
{{STRUCTURE_2oi4| PDB=2oi4 | SCENE= }}
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'''Crystal structure of human PIM1 in complex with fluorinated ruthenium pyridocarbazole'''
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===Crystal structure of human PIM1 in complex with fluorinated ruthenium pyridocarbazole===
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==Overview==
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A general route to ruthenium pyridocarbazole half-sandwich complexes is presented and applied to the synthesis of sixteen new compounds, many of which have modulated protein kinase inhibition properties. For example, the incorporation of a fluorine into the pyridine moiety increases the binding affinity for glycogen synthase kinase 3 by almost one order of magnitude. These data are supplemented with cyclic voltammetry experiments and a protein co-crystallographic study.
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(as it appears on PubMed at http://www.pubmed.gov), where 17406720 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17406720}}
==About this Structure==
==About this Structure==
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[[Category: Atp-binding,phosphorylation]]
[[Category: Atp-binding,phosphorylation]]
[[Category: Transferase,pim1,kinase]]
[[Category: Transferase,pim1,kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:58:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:18:20 2008''

Revision as of 00:18, 29 July 2008

Image:2oi4.png

Template:STRUCTURE 2oi4

Crystal structure of human PIM1 in complex with fluorinated ruthenium pyridocarbazole

Template:ABSTRACT PUBMED 17406720

About this Structure

2OI4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Ruthenium half-sandwich complexes as protein kinase inhibitors: derivatization of the pyridocarbazole pharmacophore ligand., Pagano N, Maksimoska J, Bregman H, Williams DS, Webster RD, Xue F, Meggers E, Org Biomol Chem. 2007 Apr 21;5(8):1218-27. Epub 2007 Mar 20. PMID:17406720

Page seeded by OCA on Tue Jul 29 03:18:20 2008

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