2g0b

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[[Image:2g0b.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2g0b| PDB=2g0b | SCENE= }}
{{STRUCTURE_2g0b| PDB=2g0b | SCENE= }}
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'''The structure of FeeM, an N-acyl amino acid synthase from uncultured soil microbes'''
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===The structure of FeeM, an N-acyl amino acid synthase from uncultured soil microbes===
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==Overview==
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Attempts to access antibiotics by capturing biosynthetic genes and pathways directly from environmental DNA, which is overwhelmingly derived from uncultured bacteria, have revealed a large and previously unknown family of N-acyl amino acid synthases (NASs). The structure of the NAS FeeM reveals structural similarity to the GCN5-related N-acyl transferases and acylhomoserine lactone synthases. The overall structure has a central beta sheet with alpha helices on both sides. A bound product at a cleft in the beta sheet identifies the active site and the structural basis for catalysis, and sequence conservation in this region indicates a bias for recognition over speed. FeeM interacts with an acyl carrier protein (FeeL), and the structure, mutagenesis, and enzymatic measurements reveal that a small hydrophobic pocket in alpha helix 5 dominates binding of FeeM to FeeL. The structural and mechanistic analyses suggest that the products of FeeM could be bacterial signaling agents.
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(as it appears on PubMed at http://www.pubmed.gov), where 16962973 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16962973}}
==About this Structure==
==About this Structure==
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[[Category: N-acyl transferase]]
[[Category: N-acyl transferase]]
[[Category: Protein-product complex]]
[[Category: Protein-product complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:32:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:22:10 2008''

Revision as of 00:22, 29 July 2008

Image:2g0b.png

Template:STRUCTURE 2g0b

The structure of FeeM, an N-acyl amino acid synthase from uncultured soil microbes

Template:ABSTRACT PUBMED 16962973

About this Structure

2G0B is a Single protein structure of sequence from Uncultured bacterium. Full crystallographic information is available from OCA.

Reference

FeeM, an N-acyl amino acid synthase from an uncultured soil microbe: structure, mechanism, and acyl carrier protein binding., Van Wagoner RM, Clardy J, Structure. 2006 Sep;14(9):1425-35. PMID:16962973

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