1oz9
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(New page: 200px<br /><applet load="1oz9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oz9, resolution 1.894Å" /> '''Crystal structure o...)
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Revision as of 21:11, 20 November 2007
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Crystal structure of AQ_1354, a hypothetical protein from Aquifex aeolicus
Overview
The crystal structure of a hypothetical protein AQ_1354 (gi 2983779) from, the hyperthermophilic bacteria Aquifex aeolicus has been determined using, X-ray crystallography. As found in many structural genomics studies, this, protein is not associated with any known function based on its amino-acid, sequence. PSI-BLAST analysis against a non-redundant sequence database, gave 68 similar sequences referred to as 'conserved hypothetical proteins', from the uncharacterized protein family UPF0054 (accession No. PF02310)., Crystallographic analysis revealed that the overall fold of this protein, consists of one central alpha-helix surrounded by a four-stranded, beta-sheet and four other alpha-helices. Structure-based homology analysis, with DALI revealed that the structure has a moderate to good resemblance, to metal-dependent proteinases such as collagenases and gelatinases, thus, suggesting its possible molecular function. However, experimental tests, for collagenase and gelatinase-type function show no detectable activity, under standard assay conditions. Therefore, we suggest either that the, members of the UPF0054 family have a similar fold but different, biochemical functions to those of collagenases and gelatinases or that, they have a similar function but perform it under different conditions.
About this Structure
1OZ9 is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.
Reference
Structure of the hypothetical protein AQ_1354 from Aquifex aeolicus., Oganesyan V, Busso D, Brandsen J, Chen S, Jancarik J, Kim R, Kim SH, Acta Crystallogr D Biol Crystallogr. 2003 Jul;59(Pt 7):1219-23. Epub 2003, Jun 27. PMID:12832766
Page seeded by OCA on Tue Nov 20 23:19:01 2007
Categories: Aquifex aeolicus | Single protein | BSGC, Berkeley.Structural.Genomics.Center. | Brandsen, J. | Busso, D. | Chen, S. | Jancarik, J. | Kim, R. | Kim, S.H. | Oganesyan, V. | Berkeley structural genomics center | Bsgc structure funded by nih | Matrix metalloproteinase type fold | Protein structure initiative | Psi | Structural genomics
