2hm5

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[[Image:2hm5.jpg|left|200px]]
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{{Seed}}
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[[Image:2hm5.png|left|200px]]
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{{STRUCTURE_2hm5| PDB=2hm5 | SCENE= }}
{{STRUCTURE_2hm5| PDB=2hm5 | SCENE= }}
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'''NW1, K21P, Structural Species II'''
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===NW1, K21P, Structural Species II===
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==Overview==
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Protein structures cluster into families of folds that can result from extremely different amino acid sequences [1]. Because the enormous amount of genetic information generates a limited number of protein folds [2], a particular domain structure often assumes numerous functions. How new protein structures and new functions evolve under these limitations remains elusive. Molecular evolution may be driven by the ability of biomacromolecules to adopt multiple conformations as a bridge between different folds [3-6]. This could allow proteins to explore new structures and new tasks while part of the structural ensemble retains the initial conformation and function as a safeguard [7]. Here we show that a global structural switch can arise from single amino acid changes in cysteine-rich domains (CRD) of cnidarian nematocyst proteins. The ability of these CRDs to form two structures with different disulfide patterns from an identical cysteine pattern is distinctive [8]. By applying a structure-based mutagenesis approach, we demonstrate that a cysteine-rich domain can interconvert between two natively occurring domain structures via a bridge state containing both structures. Comparing cnidarian CRD sequences leads us to believe that the mutations we introduced to stabilize each structure reflect the birth of new protein folds in evolution.
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The line below this paragraph, {{ABSTRACT_PUBMED_17240343}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17240343 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17240343}}
==About this Structure==
==About this Structure==
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2HM5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hydra_vulgaris Hydra vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HM5 OCA].
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2HM5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hydra_vulgaris Hydra vulgaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HM5 OCA].
==Reference==
==Reference==
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[[Category: Molecular evolution]]
[[Category: Molecular evolution]]
[[Category: Nematocyst]]
[[Category: Nematocyst]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:26:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:29:27 2008''

Revision as of 00:29, 29 July 2008

Image:2hm5.png

Template:STRUCTURE 2hm5

NW1, K21P, Structural Species II

Template:ABSTRACT PUBMED 17240343

About this Structure

2HM5 is a Single protein structure of sequence from Hydra vulgaris. Full experimental information is available from OCA.

Reference

Continuous molecular evolution of protein-domain structures by single amino acid changes., Meier S, Jensen PR, David CN, Chapman J, Holstein TW, Grzesiek S, Ozbek S, Curr Biol. 2007 Jan 23;17(2):173-8. PMID:17240343

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