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1xmo

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{{STRUCTURE_1xmo| PDB=1xmo | SCENE= }}
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'''Crystal Structure of mnm5U34t6A37-tRNALysUUU Complexed with AAG-mRNA in the Decoding Center'''
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===Crystal Structure of mnm5U34t6A37-tRNALysUUU Complexed with AAG-mRNA in the Decoding Center===
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==Overview==
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The natural modification of specific nucleosides in many tRNAs is essential during decoding of mRNA by the ribosome. For example, tRNA(Lys)(UUU) requires the modification N6-threonylcarbamoyladenosine at position 37 (t(6)A37), adjacent and 3' to the anticodon, to bind AAA in the A site of the ribosomal 30S subunit. Moreover, it can only bind both AAA and AAG lysine codons when doubly modified with t(6)A37 and either 5-methylaminomethyluridine or 2-thiouridine at the wobble position (mnm(5)U34 or s(2)U34). Here we report crystal structures of modified tRNA anticodon stem-loops bound to the 30S ribosomal subunit with lysine codons in the A site. These structures allow the rationalization of how modifications in the anticodon loop enable decoding of both lysine codons AAA and AAG.
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(as it appears on PubMed at http://www.pubmed.gov), where 15558052 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15558052}}
==About this Structure==
==About this Structure==
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[[Category: Ribosome]]
[[Category: Ribosome]]
[[Category: Trna modification]]
[[Category: Trna modification]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:13:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:31:35 2008''

Revision as of 00:31, 29 July 2008

Image:1xmo.png

Template:STRUCTURE 1xmo

Crystal Structure of mnm5U34t6A37-tRNALysUUU Complexed with AAG-mRNA in the Decoding Center

Template:ABSTRACT PUBMED 15558052

About this Structure

1XMO is a Protein complex structure of sequences from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

The role of modifications in codon discrimination by tRNA(Lys)UUU., Murphy FV 4th, Ramakrishnan V, Malkiewicz A, Agris PF, Nat Struct Mol Biol. 2004 Dec;11(12):1186-91. Epub 2004 Nov 21. PMID:15558052

Page seeded by OCA on Tue Jul 29 03:31:35 2008

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