2gom

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{{STRUCTURE_2gom| PDB=2gom | SCENE= }}
{{STRUCTURE_2gom| PDB=2gom | SCENE= }}
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'''Crystal structure of Efb-C from Staphylococcus aureus'''
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===Crystal structure of Efb-C from Staphylococcus aureus===
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==Overview==
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To provide insight into bacterial suppression of complement-mediated immunity, we present here structures of a bacterial complement inhibitory protein, both free and bound to its complement target. The 1.25-A structure of the complement component C3-inhibitory domain of Staphylococcus aureus extracellular fibrinogen-binding protein (Efb-C) demonstrated a helical motif involved in complement regulation, whereas the 2.2-A structure of Efb-C bound to the C3d domain of human C3 allowed insight into the recognition of complement proteins by invading pathogens. Our structure-function studies provided evidence for a previously unrecognized mode of complement inhibition whereby Efb-C binds to native C3 and alters the solution conformation of C3 in a way that renders it unable to participate in successful 'downstream' activation of the complement response.
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(as it appears on PubMed at http://www.pubmed.gov), where 17351618 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17351618}}
==About this Structure==
==About this Structure==
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[[Category: Hammel, M.]]
[[Category: Hammel, M.]]
[[Category: Three-helix closed bundle with left-hand twist]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:20:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:32:26 2008''

Revision as of 00:32, 29 July 2008

Image:2gom.png

Template:STRUCTURE 2gom

Crystal structure of Efb-C from Staphylococcus aureus

Template:ABSTRACT PUBMED 17351618

About this Structure

2GOM is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

A structural basis for complement inhibition by Staphylococcus aureus., Hammel M, Sfyroera G, Ricklin D, Magotti P, Lambris JD, Geisbrecht BV, Nat Immunol. 2007 Apr;8(4):430-7. Epub 2007 Mar 11. PMID:17351618

Page seeded by OCA on Tue Jul 29 03:32:26 2008

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