1oxj

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{{STRUCTURE_1oxj| PDB=1oxj | SCENE= }}
{{STRUCTURE_1oxj| PDB=1oxj | SCENE= }}
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'''Crystal structure of the Smaug RNA binding domain'''
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===Crystal structure of the Smaug RNA binding domain===
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==Overview==
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The Nanos protein gradient in Drosophila, required for proper abdominal segmentation, is generated in part via translational repression of its mRNA by Smaug. We report here the crystal structure of the Smaug RNA binding domain, which shows no sequence homology to any previously characterized RNA binding motif. The structure reveals an unusual makeup in which a SAM domain, a common protein-protein interaction module, is affixed to a pseudo-HEAT repeat analogous topology (PHAT) domain. Unexpectedly, we find through a combination of structural and genetic analysis that it is primarily the SAM domain that interacts specifically with the appropriate nanos mRNA regulatory sequence. Therefore, in addition to their previously characterized roles in protein-protein interactions, some SAM domains play crucial roles in RNA binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 12820967 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12820967}}
==About this Structure==
==About this Structure==
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[[Category: Rna-binding protein]]
[[Category: Rna-binding protein]]
[[Category: Sam domain]]
[[Category: Sam domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:24:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:34:52 2008''

Revision as of 00:34, 29 July 2008

Image:1oxj.png

Template:STRUCTURE 1oxj

Crystal structure of the Smaug RNA binding domain

Template:ABSTRACT PUBMED 12820967

About this Structure

1OXJ is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

RNA recognition via the SAM domain of Smaug., Green JB, Gardner CD, Wharton RP, Aggarwal AK, Mol Cell. 2003 Jun;11(6):1537-48. PMID:12820967

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