2v5y

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2v5y.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2v5y.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2v5y| PDB=2v5y | SCENE= }}
{{STRUCTURE_2v5y| PDB=2v5y | SCENE= }}
-
'''CRYSTAL STRUCTURE OF THE RECEPTOR PROTEIN TYROSINE PHOSPHATASE MU ECTODOMAIN'''
+
===CRYSTAL STRUCTURE OF THE RECEPTOR PROTEIN TYROSINE PHOSPHATASE MU ECTODOMAIN===
-
==Overview==
+
<!--
-
Cell-cell contacts are fundamental to multicellular organisms and are subject to exquisite levels of control. Human RPTPmu is a type IIB receptor protein tyrosine phosphatase that both forms an adhesive contact itself and is involved in regulating adhesion by dephosphorylating components of cadherin-catenin complexes. Here we describe a 3.1 angstrom crystal structure of the RPTPmu ectodomain that forms a homophilic trans (antiparallel) dimer with an extended and rigid architecture, matching the dimensions of adherens junctions. Cell surface expression of deletion constructs induces intercellular spacings that correlate with the ectodomain length. These data suggest that the RPTPmu ectodomain acts as a distance gauge and plays a key regulatory function, locking the phosphatase to its appropriate functional location.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17761881}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17761881 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17761881}}
==About this Structure==
==About this Structure==
Line 41: Line 45:
[[Category: Receptor protein tyrosine phosphatase]]
[[Category: Receptor protein tyrosine phosphatase]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:14:21 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:39:45 2008''

Revision as of 00:39, 29 July 2008

Image:2v5y.png

Template:STRUCTURE 2v5y

CRYSTAL STRUCTURE OF THE RECEPTOR PROTEIN TYROSINE PHOSPHATASE MU ECTODOMAIN

Template:ABSTRACT PUBMED 17761881

About this Structure

2V5Y is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism., Aricescu AR, Siebold C, Choudhuri K, Chang VT, Lu W, Davis SJ, van der Merwe PA, Jones EY, Science. 2007 Aug 31;317(5842):1217-20. PMID:17761881

Page seeded by OCA on Tue Jul 29 03:39:45 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2v5y"
Personal tools