1w8a

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[[Image:1w8a.gif|left|200px]]
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{{Seed}}
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[[Image:1w8a.png|left|200px]]
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{{STRUCTURE_1w8a| PDB=1w8a | SCENE= }}
{{STRUCTURE_1w8a| PDB=1w8a | SCENE= }}
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'''THIRD LRR DOMAIN OF DROSOPHILA SLIT'''
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===THIRD LRR DOMAIN OF DROSOPHILA SLIT===
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==Overview==
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Recognition of the large secreted protein Slit by receptors of the Robo family provides fundamental signals in axon guidance and other developmental processes. In Drosophila, Slit-Robo signalling regulates midline crossing and the lateral position of longitudinal axon tracts. We report the functional dissection of Drosophila Slit, using structure analysis, site-directed mutagenesis and in vitro assays. The N-terminal region of Slit consists of a tandem array of four independently folded leucine-rich repeat (LRR) domains, connected by disulphide-tethered linkers. All three Drosophila Robos were found to compete for a single highly conserved site on the concave face of the second LRR domain of Slit. We also found that this domain is sufficient for biological activity in a chemotaxis assay. Other Slit activities may require Slit dimerisation mediated by the fourth LRR domain. Our results show that a small portion of Slit is able to induce Robo signalling and indicate that the distinct functions of Drosophila Robos are encoded in their divergent cytosolic domains.
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(as it appears on PubMed at http://www.pubmed.gov), where 15496984 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15496984}}
==About this Structure==
==About this Structure==
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[[Category: Secreted protein]]
[[Category: Secreted protein]]
[[Category: Signal protein]]
[[Category: Signal protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:17:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:45:50 2008''

Revision as of 00:45, 29 July 2008

Image:1w8a.png

Template:STRUCTURE 1w8a

THIRD LRR DOMAIN OF DROSOPHILA SLIT

Template:ABSTRACT PUBMED 15496984

About this Structure

1W8A is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Binding site for Robo receptors revealed by dissection of the leucine-rich repeat region of Slit., Howitt JA, Clout NJ, Hohenester E, EMBO J. 2004 Nov 10;23(22):4406-12. Epub 2004 Oct 21. PMID:15496984

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