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1ypz

From Proteopedia

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[[Image:1ypz.gif|left|200px]]
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[[Image:1ypz.png|left|200px]]
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{{STRUCTURE_1ypz| PDB=1ypz | SCENE= }}
{{STRUCTURE_1ypz| PDB=1ypz | SCENE= }}
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'''Immune receptor'''
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===Immune receptor===
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==Overview==
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Gammadelta T cell receptors (TCRs), alphabeta TCRs, and antibodies are the three lineages of somatically recombined antigen receptors. The structural basis for ligand recognition is well defined for alphabeta TCR and antibodies but is lacking for gammadelta TCRs. We present the 3.4 A structure of the murine gammadelta TCR G8 bound to its major histocompatibility complex (MHC) class Ib ligand, T22. G8 predominantly uses germline-encoded residues of its delta chain complementarity-determining region 3 (CDR3) loop to bind T22 in an orientation substantially different from that seen in alphabeta TCR/peptide-MHC. That junctionally encoded G8 residues play an ancillary role in binding suggests a fusion of innate and adaptive recognition strategies.
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(as it appears on PubMed at http://www.pubmed.gov), where 15821084 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15821084}}
==Disease==
==Disease==
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[[Category: T cell receptor delta]]
[[Category: T cell receptor delta]]
[[Category: T-cell receptor gamma chain]]
[[Category: T-cell receptor gamma chain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:37:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:49:47 2008''

Revision as of 00:49, 29 July 2008

Image:1ypz.png

Template:STRUCTURE 1ypz

Contents

Immune receptor

Template:ABSTRACT PUBMED 15821084

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

1YPZ is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22., Adams EJ, Chien YH, Garcia KC, Science. 2005 Apr 8;308(5719):227-31. PMID:15821084

Page seeded by OCA on Tue Jul 29 03:49:47 2008

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