3bx5

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{{STRUCTURE_3bx5| PDB=3bx5 | SCENE= }}
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'''P38 alpha map kinase complexed with BMS-640994'''
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===P38 alpha map kinase complexed with BMS-640994===
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==Overview==
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A novel structural class of p38alpha MAP kinase inhibitors has been identified via iterative SAR studies of a focused deck screen hit. Optimization of the lead series generated 6e, BMS-640994, a potent and selective p38alpha inhibitor that is orally efficacious in rodent models of acute and chronic inflammation.
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{{ABSTRACT_PUBMED_18313298}}
==About this Structure==
==About this Structure==
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[[Category: Signaling protein]]
[[Category: Signaling protein]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:52:30 2008''

Revision as of 00:52, 29 July 2008

Image:3bx5.png

Template:STRUCTURE 3bx5

P38 alpha map kinase complexed with BMS-640994

Template:ABSTRACT PUBMED 18313298

About this Structure

3BX5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)-A potent and efficacious p38alpha MAP kinase inhibitor., Hynes J Jr, Wu H, Pitt S, Shen DR, Zhang R, Schieven GL, Gillooly KM, Shuster DJ, Taylor TL, Yang X, McIntyre KW, McKinnon M, Zhang H, Marathe PH, Doweyko AM, Kish K, Kiefer SE, Sack JS, Newitt JA, Barrish JC, Dodd J, Leftheris K, Bioorg Med Chem Lett. 2008 Mar 15;18(6):1762-7. Epub 2008 Feb 16. PMID:18313298

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