2obu

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[[Image:2obu.gif|left|200px]]
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[[Image:2obu.png|left|200px]]
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{{STRUCTURE_2obu| PDB=2obu | SCENE= }}
{{STRUCTURE_2obu| PDB=2obu | SCENE= }}
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'''Solution structure of GIP in TFE/water'''
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===Solution structure of GIP in TFE/water===
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==Overview==
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Glucose-dependent insulinotropic polypeptide (GIP) is a gastrointestinal incretin hormone, which modulates physiological insulin secretion. Because of its glucose-sensitive insulinotropic activity, there has been a considerable interest in utilizing the hormone as a potential treatment for type 2 diabetes. Structural parameters obtained from NMR spectroscopy combined with molecular modeling techniques play a vital role in the design of new therapeutic drugs. Therefore, to understand the structural requirements for the biological activity of GIP, the solution structure of GIP was investigated by circular dichroism (CD) followed by proton nuclear magnetic resonance (NMR) spectroscopy. CD studies showed an increase in the helical character of the peptide with increasing concentration of trifluoroethanol (TFE) up to 50%. Therefore, the solution structure of GIP in 50% TFE was determined. It was found that there was an alpha-helix between residues 6 and 29, which tends to extend further up to residue 36. The implications of the C-terminal extended helical segment in the inhibitory properties of GIP on gastric acid secretion are discussed. It is shown that the adoption by GIP of an alpha-helical secondary structure is a requirement for its biological activity. Knowledge of the solution structure of GIP will help in the understanding of how the peptide interacts with its receptor and aids in the design of new therapeutic agents useful for the treatment of diabetes.
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The line below this paragraph, {{ABSTRACT_PUBMED_17393464}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17393464 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17393464}}
==About this Structure==
==About this Structure==
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2OBU is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OBU OCA].
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2OBU is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OBU OCA].
==Reference==
==Reference==
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[[Category: Nmr]]
[[Category: Nmr]]
[[Category: Obesity]]
[[Category: Obesity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:34:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:53:15 2008''

Revision as of 00:53, 29 July 2008

Image:2obu.png

Template:STRUCTURE 2obu

Solution structure of GIP in TFE/water

Template:ABSTRACT PUBMED 17393464

About this Structure

2OBU is a Single protein structure. Full experimental information is available from OCA.

Reference

The bioactive conformation of glucose-dependent insulinotropic polypeptide by NMR and CD spectroscopy., Alana I, Malthouse JP, O'Harte FP, Hewage CM, Proteins. 2007 Jul 1;68(1):92-9. PMID:17393464

Page seeded by OCA on Tue Jul 29 03:53:15 2008

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