2nv6

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{{STRUCTURE_2nv6| PDB=2nv6 | SCENE= }}
{{STRUCTURE_2nv6| PDB=2nv6 | SCENE= }}
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'''Mycobacterium tuberculosis InhA (S94A) bound with INH-NAD adduct'''
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===Mycobacterium tuberculosis InhA (S94A) bound with INH-NAD adduct===
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==Overview==
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Isoniazid is one of the most effective antituberculosis drugs, yet its precise mechanism of action is still controversial. Using specialized linkage transduction, a single point mutation allele (S94A) within the putative target gene inhA was transferred in Mycobacterium tuberculosis. The inhA(S94A) allele was sufficient to confer clinically relevant levels of resistance to isoniazid killing and inhibition of mycolic acid biosynthesis. This resistance correlated with the decreased binding of the INH-NAD inhibitor to InhA, as shown by enzymatic and X-ray crystallographic analyses, and establishes InhA as the primary target of isoniazid action in M. tuberculosis.
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(as it appears on PubMed at http://www.pubmed.gov), where 16906155 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16906155}}
==About this Structure==
==About this Structure==
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[[Category: S94a]]
[[Category: S94a]]
[[Category: Tuberculosis]]
[[Category: Tuberculosis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:53:41 2008''

Revision as of 00:53, 29 July 2008

Image:2nv6.png

Template:STRUCTURE 2nv6

Mycobacterium tuberculosis InhA (S94A) bound with INH-NAD adduct

Template:ABSTRACT PUBMED 16906155

About this Structure

2NV6 is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid., Vilcheze C, Wang F, Arai M, Hazbon MH, Colangeli R, Kremer L, Weisbrod TR, Alland D, Sacchettini JC, Jacobs WR Jr, Nat Med. 2006 Sep;12(9):1027-9. Epub 2006 Aug 13. PMID:16906155

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