2guc

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{{STRUCTURE_2guc| PDB=2guc | SCENE= }}
{{STRUCTURE_2guc| PDB=2guc | SCENE= }}
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'''Crystal structure of a complex of griffithsin with mannose at 1.78 A resolution.'''
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===Crystal structure of a complex of griffithsin with mannose at 1.78 A resolution.===
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==Overview==
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The crystal structure of griffithsin, an antiviral lectin from the red alga Griffithsia sp., was solved and refined at 1.3 A resolution for the free protein and 0.94 A for a complex with mannose. Griffithsin molecules form a domain-swapped dimer, in which two beta strands of one molecule complete a beta prism consisting of three four-stranded sheets, with an approximate 3-fold axis, of another molecule. The structure of each monomer bears close resemblance to jacalin-related lectins, but its dimeric structure is unique. The structures of complexes of griffithsin with mannose and N-acetylglucosamine defined the locations of three almost identical carbohydrate binding sites on each monomer. We have also shown that griffithsin is a potent inhibitor of the coronavirus responsible for severe acute respiratory syndrome (SARS). Antiviral potency of griffithsin is likely due to the presence of multiple, similar sugar binding sites that provide redundant attachment points for complex carbohydrate molecules present on viral envelopes.
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{{ABSTRACT_PUBMED_16843894}}
==About this Structure==
==About this Structure==
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[[Category: Mannose binding]]
[[Category: Mannose binding]]
[[Category: Sar]]
[[Category: Sar]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:32:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:56:31 2008''

Revision as of 00:56, 29 July 2008

Image:2guc.png

Template:STRUCTURE 2guc

Crystal structure of a complex of griffithsin with mannose at 1.78 A resolution.

Template:ABSTRACT PUBMED 16843894

About this Structure

2GUC is a Single protein structure of sequence from Griffithsia. Full crystallographic information is available from OCA.

Reference

Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding., Ziolkowska NE, O'Keefe BR, Mori T, Zhu C, Giomarelli B, Vojdani F, Palmer KE, McMahon JB, Wlodawer A, Structure. 2006 Jul;14(7):1127-35. PMID:16843894

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