1wc8

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{{STRUCTURE_1wc8| PDB=1wc8 | SCENE= }}
{{STRUCTURE_1wc8| PDB=1wc8 | SCENE= }}
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'''THE CRYSTAL STRUCTURE OF MOUSE BET3P'''
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===THE CRYSTAL STRUCTURE OF MOUSE BET3P===
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==Overview==
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Transport protein particle (TRAPP) is a large multiprotein complex involved in endoplasmic reticulum-to-Golgi and intra-Golgi traffic. TRAPP specifically and persistently resides on Golgi membranes. Neither the mechanism of the subcellular localization nor the function of any of the individual TRAPP components is known. Here, the crystal structure of mouse Bet3p (bet3), a conserved TRAPP component, reveals a dimeric structure with hydrophobic channels. The channel entrances are located on a putative membrane-interacting surface that is distinctively flat, wide and decorated with positively charged residues. Charge-inversion mutations on the flat surface of the highly conserved yeast Bet3p led to conditional lethality, incorrect localization and membrane trafficking defects. A channel-blocking mutation led to similar defects. These data delineate a molecular mechanism of Golgi-specific targeting and anchoring of Bet3p involving the charged surface and insertion of a Golgi-specific hydrophobic moiety into the channels. This essential subunit could then direct other TRAPP components to the Golgi.
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(as it appears on PubMed at http://www.pubmed.gov), where 15608655 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15608655}}
==About this Structure==
==About this Structure==
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[[Category: Trapp]]
[[Category: Trapp]]
[[Category: Vesicle transport]]
[[Category: Vesicle transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:58:06 2008''

Revision as of 00:58, 29 July 2008

Image:1wc8.png

Template:STRUCTURE 1wc8

THE CRYSTAL STRUCTURE OF MOUSE BET3P

Template:ABSTRACT PUBMED 15608655

About this Structure

1WC8 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of bet3 reveals a novel mechanism for Golgi localization of tethering factor TRAPP., Kim YG, Sohn EJ, Seo J, Lee KJ, Lee HS, Hwang I, Whiteway M, Sacher M, Oh BH, Nat Struct Mol Biol. 2005 Jan;12(1):38-45. Epub 2004 Dec 19. PMID:15608655

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