1pdu

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[[Image:1pdu.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1pdu| PDB=1pdu | SCENE= }}
{{STRUCTURE_1pdu| PDB=1pdu | SCENE= }}
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'''Ligand-binding domain of Drosophila orphan nuclear receptor DHR38'''
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===Ligand-binding domain of Drosophila orphan nuclear receptor DHR38===
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==Overview==
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Ecdysteroid pulses trigger the major developmental transitions during the Drosophila life cycle. These hormonal responses are thought to be mediated by the ecdysteroid receptor (EcR) and its heterodimeric partner Ultraspiracle (USP). We provide evidence for a second ecdysteroid signaling pathway mediated by DHR38, the Drosophila ortholog of the mammalian NGFI-B subfamily of orphan nuclear receptors. DHR38 also heterodimerizes with USP, and this complex responds to a distinct class of ecdysteroids in a manner that is independent of EcR. This response is unusual in that it does not involve direct binding of ecdysteroids to either DHR38 or USP. X-ray crystallographic analysis of DHR38 reveals the absence of both a classic ligand binding pocket and coactivator binding site, features that seem to be common to all NGFI-B subfamily members. Taken together, these data reveal the existence of a separate structural class of nuclear receptors that is conserved from fly to humans.
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(as it appears on PubMed at http://www.pubmed.gov), where 12809604 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12809604}}
==About this Structure==
==About this Structure==
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[[Category: Ligand-binding domain]]
[[Category: Ligand-binding domain]]
[[Category: Nuclear receptor]]
[[Category: Nuclear receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:58:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:58:05 2008''

Revision as of 00:58, 29 July 2008

Image:1pdu.png

Template:STRUCTURE 1pdu

Ligand-binding domain of Drosophila orphan nuclear receptor DHR38

Template:ABSTRACT PUBMED 12809604

About this Structure

1PDU is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway., Baker KD, Shewchuk LM, Kozlova T, Makishima M, Hassell A, Wisely B, Caravella JA, Lambert MH, Reinking JL, Krause H, Thummel CS, Willson TM, Mangelsdorf DJ, Cell. 2003 Jun 13;113(6):731-42. PMID:12809604

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