1xxw

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{{STRUCTURE_1xxw| PDB=1xxw | SCENE= }}
{{STRUCTURE_1xxw| PDB=1xxw | SCENE= }}
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'''Structure of zinc induced heterodimer of two calcium free isoforms of phospholipase A2 from Naja naja sagittifera at 2.7A resolution'''
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===Structure of zinc induced heterodimer of two calcium free isoforms of phospholipase A2 from Naja naja sagittifera at 2.7A resolution===
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==Overview==
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The crystal structure of a zinc-induced heterodimer of two metal-free isoforms of a cobra venom phospholipase A(2) has been determined at 2.7 angstroms resolution. The crystals belong to space group P4(1), with unit-cell parameters a = b = 65.5, c = 58.4 angstroms, and have a single dimer in the asymmetric unit. The structure has been refined to R(cryst) and R(free) factors of 0.188 and 0.232, respectively. The two isoforms have a sequence identity of 82%. The zinc ion forms a fivefold coordination with a trigonal bipyramidal geometry involving one O atom each from Asp24 and Asn112 from molecule A and Asp24 from molecule B and two water molecules. Both molecules of the dimer are inactive. Molecule A is inactive because Arg31 (B) binds to Asp49 (A), while an acetate ion has displaced the essential water molecule and interacts with His48 (A). On the other hand, Arg31 (A) interacts with the calcium-binding loop of molecule B, resulting in an altered conformation of the loop. The absence of a calcium ion, loss of the essential water molecule and the altered conformation of the calcium-binding loop may be the reasons for the loss of activity of molecule B.
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(as it appears on PubMed at http://www.pubmed.gov), where 15735340 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15735340}}
==About this Structure==
==About this Structure==
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[[Category: Venom]]
[[Category: Venom]]
[[Category: Zinc induced]]
[[Category: Zinc induced]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:38:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:58:40 2008''

Revision as of 00:58, 29 July 2008

Image:1xxw.png

Template:STRUCTURE 1xxw

Structure of zinc induced heterodimer of two calcium free isoforms of phospholipase A2 from Naja naja sagittifera at 2.7A resolution

Template:ABSTRACT PUBMED 15735340

About this Structure

1XXW is a Protein complex structure of sequences from Naja sagittifera. Full crystallographic information is available from OCA.

Reference

Structure of the zinc-induced heterodimer of two calcium-free isoforms of phospholipase A2 from Naja naja sagittifera at 2.7 angstroms resolution., Jabeen T, Sharma S, Singh N, Singh RK, Verma AK, Paramasivam M, Srinivasan A, Singh TP, Acta Crystallogr D Biol Crystallogr. 2005 Mar;61(Pt 3):302-8. Epub 2005, Feb 24. PMID:15735340

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